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Daicel Chiral Technologies (China)CO.,LTD
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Product Name:4-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
CAS:1957236-10-0
Purity:95% Package:250MG;1G Remarks:209696
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Jilin Province Woda Biotechnology Co., Ltd.
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13504435624 |
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Product Name:4-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
CAS:1957236-10-0
Purity:98%
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Binhai gill polypeptide co. LTD
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021-61263389 13524856427 |
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Joetang@glschina.com |
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Product Name:4-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
CAS:1957236-10-0
Package:1g/
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Nanjing Bestfluorodrug Pharmaceutical Technology CO.,LTD
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025-86755008 17751752005 |
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Product Name:4-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
CAS:1957236-10-0
Purity:95%+ Package:1g;5g;10g,25g
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Shanghai Easy CDMO Co.,Ltd
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021-61734564 13854185395; |
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info@easycdmo.com |
| Products Intro: |
Product Name:4-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
CAS:1957236-10-0
Purity:98% Package:5g；10g；20g；100g；100kg
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| | 4-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione Basic information |
| Product Name: | 4-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione | | Synonyms: | 4-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione;1H-Isoindole-1,3(2H)-dione, 4-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]-2-(2,6-dioxo-3-piperidinyl)-;Thalidomide-O-PEG2-amine;4-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;4-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione;Thalidomide-4-PEG3-NH2;4-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione;Thalidomide-O-PEG2-Amine TFA salt | | CAS: | 1957236-10-0 | | MF: | C19H23N3O7 | | MW: | 405.4 | | EINECS: | | | Product Categories: | | | Mol File: | 1957236-10-0.mol | ![4-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione Structure](CAS/20210111/GIF/1957236-10-0.gif) |
| | 4-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione Chemical Properties |
| Boiling point | 648.7±55.0 °C(Predicted) | | density | 1.375±0.06 g/cm3(Predicted) | | solubility | DMF, DCM, methanol | | pka | 10.70±0.40(Predicted) | | Appearance | white crystalline solid |
| | 4-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione Usage And Synthesis |
| Description | Thalidomide-containing building block with PEG2-linker and amino group, which can be conjugated to other functionalized linkers and target protein ligands.
The amino group is highly reactive and can undergo reactions with carboxylic acids, activated esters (NHS, STP, etc.), carbonyls (such as ketones and aldehydes), and more.
Proteolysis targeting chimeras (PROTACs) are cell-permeable heterobifunctional molecules that can remove specific proteins from the cell. One end of such molecule contains a ligand to bind to the target, and the second end recruits the E3 ligase complex. Close proximity results in substrate polyubiquitination and subsequent protein degradation by cellular proteasome.
There are several types of E3 ligases that are practically suitable for such a purpose. Thalidomide is the ligand capable of recruiting Cereblon (CRBN) E3 ligase. | | Uses | Thalidomide-PEG3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1]. | | IC 50 | Cereblon | | References | [1] Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine.Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. DOI:10.3389/fcell.2021.629326
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-997. DOI:10.1016/j.immuni.2020.07.018 |
| | 4-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione Preparation Products And Raw materials |
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