1H-Isoindole-1,3(2H)-dione, 4-[(3-azidopropyl)amino]-2-(2,6-dioxo-3-piperidinyl)-

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1H-Isoindole-1,3(2H)-dione, 4-[(3-azidopropyl)amino]-2-(2,6-dioxo-3-piperidinyl)- Basic information
Product Name:1H-Isoindole-1,3(2H)-dione, 4-[(3-azidopropyl)amino]-2-(2,6-dioxo-3-piperidinyl)-
Synonyms:XUN-08053;4-((3-azidopropyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;Pomalidomide4'-alkylC3-azide;Poma-C3-N3;4-(3-azidopropylamino)-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione;Poma-NH-C3-N3;1H-Isoindole-1,3(2H)-dione, 4-[(3-azidopropyl)amino]-2-(2,6-dioxo-3-piperidinyl)-;4-((3-azidoethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
CAS:2357108-05-3
MF:C16H16N6O4
MW:356.34
EINECS:
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Mol File:2357108-05-3.mol
1H-Isoindole-1,3(2H)-dione, 4-[(3-azidopropyl)amino]-2-(2,6-dioxo-3-piperidinyl)- Structure
1H-Isoindole-1,3(2H)-dione, 4-[(3-azidopropyl)amino]-2-(2,6-dioxo-3-piperidinyl)- Chemical Properties
Safety Information
MSDS Information
1H-Isoindole-1,3(2H)-dione, 4-[(3-azidopropyl)amino]-2-(2,6-dioxo-3-piperidinyl)- Usage And Synthesis
DescriptionXUN-08053 is a functionalized cereblon ligand for PROTAC research and development. It incorporates an E3 ligase ligand plus an alkylC3 linker with terminal azide ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. This product has no formal name.
UsesPomalidomide 4'-alkylC3-azide (compound 2a) is an E3 ligase ligand-linker conjugate containing a Pomalidomide (HY-10984) based cereblon (CRBN) ligand and a linker. Pomalidomide 4'-alkylC3-azide can be used in the synthesis of PROTAC[1].
storageStore at -20°C
References[1] Liu H, et al. Construction of an IMiD-based azide library as a kit for PROTAC research. Org Biomol Chem. 2021 Jan 6;19(1):166-170. DOI:10.1039/d0ob02120b
1H-Isoindole-1,3(2H)-dione, 4-[(3-azidopropyl)amino]-2-(2,6-dioxo-3-piperidinyl)- Preparation Products And Raw materials
Tag:1H-Isoindole-1,3(2H)-dione, 4-[(3-azidopropyl)amino]-2-(2,6-dioxo-3-piperidinyl)-(2357108-05-3) Related Product Information
4-((2-azidoethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Nonanoic acid, 9-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- Propanoic acid, 3-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]-, 2,2,2-trifluoroacetate (1:1) Pomalidomide-NH-PEG3-azide 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]- 4-((2-(2-(2-azidoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Poma-NH-C4-N3 4-((6-azidohexyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Propanoic acid, 3-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]-, 2,2,2-trifluoroacetate (1:1) Pomalidomide-PEG2-CO2H Pomalidomide-PEG4-CO2H Propanoic acid, 3-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]-, 2,2,2-trifluoroacetate (1:1) 4-((5-azidopentyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Pomalidomide-PEG3-CO2H 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-(2-hydroxyethoxy)ethyl]amino]- E3 ligase Ligand-Linker Conjugates 50