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| | 4-((6-azidohexyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Basic information |
| Product Name: | 4-((6-azidohexyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione | | Synonyms: | 4-((6-azidohexyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;Poma-C6-N3;4-(6-azidohexylamino)-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione;Pomalidomide 4'-alkylC6-azide;Poma-NH-C6-N3;4-((6-azidoethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;4-[(6-Azidohexyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione | | CAS: | 2375555-72-7 | | MF: | C19H22N6O4 | | MW: | 398.42 | | EINECS: | | | Product Categories: | | | Mol File: | 2375555-72-7.mol |  |
| | 4-((6-azidohexyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Chemical Properties |
| | 4-((6-azidohexyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Usage And Synthesis |
| Description | HUN-55727 is a functionalized cereblon ligand for PROTAC research and development. It incorporates an E3 ligase ligand plus an alkylC6 linker with terminal azide ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. This product has no formal name. | | Uses | Pomalidomide 4'-alkylC6-azide is the Pomalidomide (HY-123324)-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide 4'-alkylC6-azide can be connected to the ligand for protein by a linker to form PROTAC[1]. | | storage | Store at -20°C | | References | [1] Liu H, et al. Construction of an IMiD-based azide library as a kit for PROTAC research. Org Biomol Chem. 2021 Jan 6;19(1):166-170. DOI:10.1039/d0ob02120b |
| | 4-((6-azidohexyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Preparation Products And Raw materials |
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