2-Chloro-4-hydroxybenzonitrile

2-Chloro-4-hydroxybenzonitrile Suppliers list

Company Name:	ShangHai DEMO Chemical Co.,Ltd
Tel:	400-021-7337 2355568890
Email:	sales@demochem.com

Company Name:	BeiJing Hwrk Chemicals Limted
Tel:	0757-86329057 18934348241
Email:	sales4.gd@hwrkchemical.com

2-Chloro-4-hydroxybenzonitrile manufacturers

2-Chloro-4-hydroxybenzonitrile Basic information

Product Name:	2-Chloro-4-hydroxybenzonitrile
Synonyms:	Chloro-4-hydroxybenzonitrile;Benzonitrile,2-chloro-4-hydroxy-;2-Chloro-4-hydroxybenzonitrile 98+%;3-Chloro-4-cyanophenol;2-Chloro-4-hydroxybenzonitrile 98%;2-Chloro-4-hydroxybenzonitrile
CAS:	3336-16-1
MF:	C7H4ClNO
MW:	153.57
EINECS:
Product Categories:	Aromatic Nitriles;C6 to C7;Cyanides/Nitriles;Nitrogen Compounds
Mol File:	3336-16-1.mol

2-Chloro-4-hydroxybenzonitrile Chemical Properties

Melting point	160 °C (dec.)(lit.)
Boiling point	323.2±27.0 °C(Predicted)
density	1.41±0.1 g/cm3(Predicted)
storage temp.	Inert atmosphere,Room Temperature
pka	6.88±0.18(Predicted)
form	powder
color	White
InChI	1S/C7H4ClNO/c8-7-3-6(10)2-1-5(7)4-9/h1-3,10H
InChIKey	BDDVAWDNVWLHDQ-UHFFFAOYSA-N
SMILES	Oc1ccc(C#N)c(Cl)c1
CAS DataBase Reference	3336-16-1

Safety Information

Hazard Codes	Xn
Risk Statements	20/21/22-36/37/38
Safety Statements	26-37/39
WGK Germany	3
HS Code	2926907090
Storage Class	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3

MSDS Information

Provider	Language
SigmaAldrich	English

2-Chloro-4-hydroxybenzonitrile Usage And Synthesis

Uses	2-Chloro-4-hydroxybenzonitrile is used for preparation of arylthioamides.
Chemical Properties	white to light yellow crystal powder
Uses	2-Chloro-4-hydroxybenzonitrile may be used in the synthesis of 6-aminophenanthridines via Suzuki-Miyaura coupling reaction. It may be used in the preparation of 5-bromo-2-chloro-4-hydroxybenzonitrile.
Synthesis	20925-27-3 3336-16-1 Step 5: 2-Chloro-4-aminobenzonitrile (25 g, 0.187 mol) was added to a stirred mixture of concentrated sulfuric acid (58 g) and water (570 mL) and heated between 49 °C and 61 °C for about 30 minutes. The suspension was cooled to about 0°C and a cold solution of sodium nitrite (13.2 g, 0.187 mol) dissolved in water (125 mL) was slowly added dropwise over a temperature range of 0°C to 6°C. After the dropwise addition was completed, stirring of the reaction mixture was continued for about 3 hours. Subsequently, urea (1.5 g) was added to the mixture to quench the excess sodium nitrite. Insoluble impurities were removed by filtration. To the filtrate was added a 50% aqueous sulfuric acid solution (600 mL) while the reaction mixture was heated to between 74 °C and 81 °C with continuous stirring until the nitrogen stopped escaping. Upon completion of the reaction, the product was separated by filtration and purified with recrystallized water to give 2-chloro-4-hydroxybenzonitrile (17.9 g, 62.5% yield, melting point 160 °C).
References	[1] Patent: US4424371, 1984, A

2-Chloro-4-hydroxybenzonitrile Preparation Products And Raw materials

Raw materials	4-Amino-2-chlorobenzonitrile-->Urea-->Water-->Sodium nitrite-->Sulfuric acid
Preparation Products	2-Chloro-4-hydroxy-benzoic acid methyl ester-->4-Benzyloxy-3-chloro-benzonitrile-->Ethyl 2-chloro-4-hydroxybenzoate

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