| Company Name: |
Alfa Chemistry |
| Tel: |
+1-5166625404; |
| Email: |
Info@alfa-chemistry.com |
Cefetrizole manufacturers
- Cefetrizole
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- $1520.00
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2026-05-11
- CAS:65307-12-2
- Purity:
- Supply Ability: 10g
- Cefetrizole
-
- $1520.00
-
2025-07-17
- CAS:65307-12-2
- Purity:
- Supply Ability: 10g
|
| | Cefetrizole Basic information |
| Product Name: | Cefetrizole | | Synonyms: | Cefetrizole;(6R,7R)-8-Oxo-7-[2-thienylacetylamino]-3-[(1H-s-triazol-3-ylthio)methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 8-oxo-7-[[2-(2-thienyl)acetyl]amino]-3-[(1H-1,2,4-triazol-5-ylthio)methyl]-, (6R,7R)- | | CAS: | 65307-12-2 | | MF: | C16H15N5O4S3 | | MW: | 437.52 | | EINECS: | | | Product Categories: | | | Mol File: | 65307-12-2.mol |  |
| | Cefetrizole Chemical Properties |
| density | 1.71±0.1 g/cm3(Predicted) | | pka | 2.65±0.50(Predicted) |
| | Cefetrizole Usage And Synthesis |
| Uses | Ceftezole is an α-Glucosidase inhibitor with an IC50 and a Ki of 2.1 μM and 0.578 μM, respectively. | | Biological Activity | Ceftezole is an α-Glucosidase inhibitor with IC50 and Ki values of 2.1 μM and 0.578 μM, respectively. | | in vitro | In in vitro α-Glucosidase assays, Ceftezole is shown to be a reversible, non-competitive inhibitor of yeast α-glucosidase with a K i value of 5.78×10 -7 M when the enzyme mixture is pretreated with ceftezole. | | in vivo | Using an in vivo streptozotocin-induced mouse model, blood glucose levels are confirmed to be decreased by 30% 20 min after Ceftezole treatment (10 mg/kg/day). Expression levels of glycogen synthase kinase-3, peroxisome proliferator-activated receptor-γ, and uncoupling protein-3 mRNA are also slightly decreased compare to controls following Ceftezole treatment[1]. | | target | IC50: 2.1 μM (α-Glucosidase)
Ki: 0.578 μM (α-Glucosidase) | | References | [1] Lee DS, et al. Ceftezole, a cephem antibiotic, is an alpha-glucosidase inhibitor with in vivo anti-diabetic activity. Int J Mol Med. 2007 Sep;20(3):379-83. PMID:17671744 |
| | Cefetrizole Preparation Products And Raw materials |
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