- Tussilagone
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- $51.00
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2026-07-15
- CAS:104012-37-5
- Purity: 99.63%
- Supply Ability: 10g
- Tussilagone
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-
2023-02-24
- CAS:104012-37-5
- Min. Order: 5mg
- Purity: ≥98%(HPLC)
- Supply Ability: 10 g
- Tussilagone
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- $1.00
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2019-07-06
- CAS:104012-37-5
- Min. Order: 1KG
- Purity: 99%
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| | Tussilagone Basic information |
| Product Name: | Tussilagone | | Synonyms: | Tussilagone;L 652469;Tussilagone, 98%, from Farfarae Flos;2-Pentenoic acid, 3-methyl-, (1S,3aR,5R,7S,7aS)-1-[(1R)-1-(acetyloxy)ethyl]octahydro-4-methylene-7-(1-methylethyl)-2-oxo-1H-inden-5-yl ester, (2E)-;(1R,3aR,5R,7S,7aS)-1-(1-acetyloxyethyl)-4-methylidene-2-oxo-7-propan-2-yl-3,3a,5,6,7,7a-hexahydro-1H-inden-5-yl](E)-3-methylpent-2-enoate;(1S,3aR,5R,7S,7aS)-1-((R)-1-Acetoxyethyl)-7-isopropyl-4-methylene-2-oxooctahydro-1H-inden-5-yl (E)-3-methylpent-2-enoate;Tussilagone-RM;Tussilagone (Standard) | | CAS: | 104012-37-5 | | MF: | C23H34O5 | | MW: | 390.51 | | EINECS: | | | Product Categories: | | | Mol File: | 104012-37-5.mol |  |
| | Tussilagone Chemical Properties |
| Boiling point | 471.3±35.0 °C(Predicted) | | density | 1.07±0.1 g/cm3 (20 ºC 760 Torr) | | storage temp. | 2-8°C | | form | Solid | | color | White to off-white | | InChIKey | CFUPNMDNSQIWBB-UUVDBSHOSA-N | | SMILES | C(O[C@@H]1C[C@@H](C(C)C)[C@@]2([H])[C@]([H])(C1=C)CC(=O)[C@@H]2[C@H](OC(C)=O)C)(=O)/C=C(\C)/CC |
| Safety Statements | 24/25 | | WGK Germany | WGK 3 | | HS Code | 29389090 | | Storage Class | 11 - Combustible Solids |
| | Tussilagone Usage And Synthesis |
| Chemical Properties | White crystalline powder, soluble in ether, chloroform, ethyl acetate, methanol, insoluble in water, derived from the flower bud of Asteraceae Tussilago farfara, Senecio kleinia Less root. | | Uses | Tussilagone, a major active component in Tussilago farfara, has anti-inflammatory effect. Tussilagone ameliorates inflammatory responses in dextran sulphate sodium-induced murine colitis. Tussilagone inhibits the inflammatory response and improves survival in cecal ligation and puncture (CLP)-induced septic mice[1][2]. | | Biological Activity | Tussilagone, the main active ingredient of Tussilago farfara, has anti-inflammatory properties. It ameliorates the inflammatory response of dextran sulfate sodium-induced colitis in mice. | | in vivo | Tussilagone administration (1 mg/kg and 10 mg/kg) produced decreased mortality and lung injury in CLP-activated septic mice. Augmented expression of cyclooxygenase (COX)-2 and TNF-α in pulmonary alveolar macrophages of septic mice were attenuated by tussilagone administration. | | References | [1] Cheon HJ, et al. Tussilagone, a major active component in Tussilago farfara, ameliorates inflammatory responses in dextran sulphate sodium-induced murine colitis. Chem Biol Interact. 2018 Oct 1;294:74-80. DOI:10.1016/j.cbi.2018.08.022
[2] Kim YK, et al. Tussilagone Inhibits the Inflammatory Response and Improves Survival in CLP-Induced SepticMice. Int J Mol Sci. 2017 Dec 18;18(12). pii: E2744. DOI:10.3390/ijms18122744 |
| | Tussilagone Preparation Products And Raw materials |
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