1-Piperidinepropanenitrile, α-[(2E)-3-(3,4-dihydroxyphenyl)-2-propen-1-ylidene]-β-oxo-, (αE)-

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1-Piperidinepropanenitrile, α-[(2E)-3-(3,4-dihydroxyphenyl)-2-propen-1-ylidene]-β-oxo-, (αE)- Basic information
Product Name:1-Piperidinepropanenitrile, α-[(2E)-3-(3,4-dihydroxyphenyl)-2-propen-1-ylidene]-β-oxo-, (αE)-
Synonyms:1-Piperidinepropanenitrile, α-[(2E)-3-(3,4-dihydroxyphenyl)-2-propen-1-ylidene]-β-oxo-, (αE)-
CAS:3033106-46-3
MF:C17H18N2O3
MW:298.34
EINECS:
Product Categories:
Mol File:3033106-46-3.mol
1-Piperidinepropanenitrile, α-[(2E)-3-(3,4-dihydroxyphenyl)-2-propen-1-ylidene]-β-oxo-, (αE)- Structure
1-Piperidinepropanenitrile, α-[(2E)-3-(3,4-dihydroxyphenyl)-2-propen-1-ylidene]-β-oxo-, (αE)- Chemical Properties
Boiling point 592.8±50.0 °C(predicted)
density 1.292±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka9.29±0.10(predicted)
Safety Information
MSDS Information
1-Piperidinepropanenitrile, α-[(2E)-3-(3,4-dihydroxyphenyl)-2-propen-1-ylidene]-β-oxo-, (αE)- Usage And Synthesis
UseshMAO-B/MB-COMT-IN-2 is a dual MAO-B/MB-COMT inhibitor (IC50s: 4.27 μΜ for hMAO-B, 2.69 μΜ for MB-COMT). hMAO-B/MB-COMT-IN-2 protects cells against oxidative damage. hMAO-B/MB-COMT-IN-2 can be used in the research of neurodegeneration disease, such as Parkinson’s Disease (PD)[1].
References[1] Daniel Chavarria, et al. Boosting caffeic acid performance as antioxidant and monoamine oxidase B/catechol-O-methyltransferase inhibitor. Eur J Med Chem. 2022 Sep 8;243:114740. DOI:10.1016/j.ejmech.2022.114740
1-Piperidinepropanenitrile, α-[(2E)-3-(3,4-dihydroxyphenyl)-2-propen-1-ylidene]-β-oxo-, (αE)- Preparation Products And Raw materials
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2-Propenamide, 2-cyano-3-(3,4-dihydroxyphenyl)-N,N-diethyl-, (2E)- 1-Piperidinepropanenitrile, α-[(2E)-3-(3,4-dihydroxyphenyl)-2-propen-1-ylidene]-β-oxo-, (αE)- (E)-N-Benzyl-2-cyano-3-(4-hydroxyphenyl)-2-propenamide SALOR-INT L470562-1EA Tyrene CR4 TYRPHOSTIN AG 835