- Asatone
-
- $74.00
-
2026-07-15
- CAS:38451-63-7
- Purity: 99.84%
- Supply Ability: 10g
- Asatone
-
- $74.00
-
2026-07-15
- CAS:38451-63-7
- Purity: 99.84%
- Supply Ability: 10g
- Asatone
-
-
2024-04-12
- CAS:38451-63-7
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 2000ton
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| | Asatone Basic information |
| Product Name: | Asatone | | Synonyms: | Asatone;1,4-Ethanonaphthalene-6,10(4H)-dione, 1,4a,5,8a-tetrahydro-1,5,5,7,9,9-hexamethoxy-3,8a-di-2-propen-1-yl-, (1R,4S,4aS,8aS)-rel-;Asatone USP/EP/BP;Asatone A;NF-κB,inhibit,Asatone,Nuclear factor-κB,Inhibitor,Nuclear factor-kappaB;rel-(1R,4S,4aS,8aS)-3,8a-Diallyl-1,5,5,7,9,9-hexamethoxy-1,4a,5,8a-tetrahydro-1,4-ethanonaphthalene-6,10(4H)-dione;Asatone, 10 mM in DMSO | | CAS: | 38451-63-7 | | MF: | C24H32O8 | | MW: | 448.51 | | EINECS: | | | Product Categories: | | | Mol File: | 38451-63-7.mol |  |
| | Asatone Chemical Properties |
| Boiling point | 536.1±50.0 °C(Predicted) | | density | 1.19±0.1 g/cm3(Predicted) | | storage temp. | 4°C, protect from light | | solubility | Soluble in DMSO | | form | Solid | | color | White to off-white |
| | Asatone Usage And Synthesis |
| Chemical Properties | Blocky white crystals, soluble in methanol, ethanol, DMSO and other organic solvents, derived from AsarumsieboldiiMiq. | | Uses | Asatone is an active component isolated from Radix et Rhizoma Asari, with anti-inflammatory effect via activation of NF-κB and donwn regulation of p-MAPK (ERK, JNK and p38) pathways[1]. | | Biological Activity | Asatone, an active ingredient isolated from Asarum, has anti-inflammatory activity by activating NF-κB and downregulating p-MAPK (ERK, JNK and p38) pathways. | | Synthesis | Asatone was prepared as follows: air-dried whole powdered air-dried powder (28 kg) of the whole plant of Asarum was extracted with 70% ethanol (3 150 L) under reflux for a total of 6 h, and then the solvent was removed under reduced pressure. The 70% ethanol extract (4360 g) was suspended in water and sequentially partitioned with light petroleum (60-90oC), CHCl3, EtOAc and n-butyl OH. The light petroleum layer (260 g) was subjected to silica gel CC elution and gradient elution with n-hexane-EtOAc (30:1 to 0:1) to give 32 fractions (P-fractions 1-32). Semi-preparative HPLC (85% MeOH in H2O) was performed on P-fraction 6 to give asatone (25 mg). | | target | | | References | [1] Chang HY, et al. Asatone Prevents Acute Lung Injury by Reducing Expressions of NF-[Formula: see text]B, MAPK and Inflammatory Cytokines. Am J Chin Med. 2018;46(3):651-671. DOI:10.1142/S0192415X18500349 |
| | Asatone Preparation Products And Raw materials |
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