4-Chloro-1H-pyrazolo[3,4-d]pyrimidin-6-amine

4-Chloro-1H-pyrazolo[3,4-d]pyrimidin-6-amine Suppliers list

Company Name:	ShangHai Movin Pharmaceutical Co., Ltd. Gold
Tel:	13681854265
Email:	info@moenpharm.com

Company Name:	Shanghai Hongle Biotechnology Co., Ltd Gold
Tel:	021-56145923; 4001631568
Email:	sales@honglebiotech.com

Company Name:	Chemsky（shanghai）International Co.,Ltd.
Tel:	021-50135380
Email:	shchemsky@sina.com

4-Chloro-1H-pyrazolo[3,4-d]pyrimidin-6-amine manufacturers

4-Chloro-1H-pyrazolo[3,4-d]pyrimidin-6-amine Basic information

Product Name:	4-Chloro-1H-pyrazolo[3,4-d]pyrimidin-6-amine
Synonyms:	4-Chloro-1H-pyrazolo[3,4-d]pyrimidin-6-ylamine;4-chloro-1H-pyrazolo[3,4-d]pyrimidin-6-amine(SALTDATA: FREE);6-Amino-4-chloro-1H-pyrazolo[3,4-d]pyrimidine;6-Amino-4-chloropyrazolo[3,4-d]pyrimidine;1H-Pyrazolo[3,4-d]pyrimidin-6-amine,4-chloro-;o[3,4-d]pyrimidin-6-amine;4-CHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDIN-6-AMINE ISO 9001：2015 REACH;4-chloro-1H-pyrazolo[3,4-d]pyrimidine-6-amine
CAS:	100644-65-3
MF:	C5H4ClN5
MW:	169.57
EINECS:
Product Categories:
Mol File:	100644-65-3.mol

4-Chloro-1H-pyrazolo[3,4-d]pyrimidin-6-amine Chemical Properties

Boiling point	282.3±50.0 °C(Predicted)
density	2.09±0.1 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
pka	9.35±0.20(Predicted)
Appearance	Light yellow to yellow Solid
InChI	InChI=1S/C5H4ClN5/c6-3-2-1-8-11-4(2)10-5(7)9-3/h1H,(H3,7,8,9,10,11)
InChIKey	ASKOHPBJRRSUSJ-UHFFFAOYSA-N
SMILES	C1(N)=NC(Cl)=C2C=NNC2=N1

Safety Information

RIDADR	UN2811
HS Code	2933599590

MSDS Information

4-Chloro-1H-pyrazolo[3,4-d]pyrimidin-6-amine Usage And Synthesis

Uses	4-Chloro-1H-pyrazolo[3,4-D]pyrimidine-6-amine is a pyrimidine derivative that can be used as a pharmaceutical intermediate.
Synthesis	5604-46-6 100644-65-3 GENERAL STEPS: A mixture of 2-amino-4,6-dichloropyrimidine-5-carbaldehyde (1.92 g, 10 mmol) and triethylamine (1.59 mL, 11.5 mmol) was added to a solvent mixture of THF (40 mL) and H2O (4 mL) at room temperature. Subsequently, hydrazine (64%, 486 μL, 10 mmol) was added slowly and dropwise. The reaction mixture was stirred continuously for 4 h at room temperature. Upon completion of the reaction, the volatiles were removed by distillation under reduced pressure. The residue was precipitated with water, and the resulting precipitate was washed with water and dried under vacuum to afford the target product 4-chloro-1H-pyrazolo[3,4-D]pyrimidin-6-amine (1.8 g, quantitatively) as a yellow solid.13C NMR (DMSO-d6, 75 MHz) δ: 161.5 (C-2), 157.5 (C-4), 153.2 (C-7a), 132.7 (C-5), 105.8 (C-4a).MS (m/z): 170 [M + H]+.
References	[1] Patent: WO2014/96423, 2014, A1. Location in patent: Page/Page column 50 [2] Patent: CN103804447, 2016, B. Location in patent: Paragraph 0076; 0082; 0083; 0084 [3] Synlett, 2011, # 13, p. 1900 - 1904 [4] Patent: WO2012/135084, 2012, A1. Location in patent: Page/Page column 17 [5] Patent: US2012/202785, 2012, A1. Location in patent: Page/Page column 262

4-Chloro-1H-pyrazolo[3,4-d]pyrimidin-6-amine Preparation Products And Raw materials

Raw materials	2-Amino-4,6-dichloro-pyrimidine-5-carbaldehyde-->Triethylamine-->Tetrahydrofuran-->HYDRAZINE-->Water
Preparation Products	1H-Pyrazolo[3,4-d]pyrimidin-6-amine, 4-(1-methylethoxy)--->1H-Pyrazolo[3,4-d]pyrimidin-6-amine, 4-propoxy--->6-Amino-1H-pyrazolo[3,4-d]pyrimidin-4(7H)-one-->1H-Pyrazolo[3,4-d]pyriMidin-6-aMine, 3-broMo-4-(1-Methylethoxy)-

Tag:4-Chloro-1H-pyrazolo[3,4-d]pyrimidin-6-amine(100644-65-3) Related Product Information

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