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| | 5-Bromo-2-[(4-methoxycarbonyl)phenoxy]pyrimidine Basic information |
| Product Name: | 5-Bromo-2-[(4-methoxycarbonyl)phenoxy]pyrimidine | | Synonyms: | Methyl 4-(5-bromopyrimidin-2-yloxy)benzoate;4-(5-Bromo-pyrimidin-2-yloxy)-benzoic acid methyl ester;4-[(5-bromo-2-pyrimidinyl)oxy]Benzoic acid methyl ester;Methyl 4-((5-bromopyrimidin-2-yl);Benzoic acid, 4-[(5-bromo-2-pyrimidinyl)oxy]-, methyl ester;5-bromo-2-[(4-methoxycarbonyl)phenoxy]pyrimidine, CAS 926304-76-9;5-Bromo-2-[(4-methoxycarbonyl)phenoxy]pyrimidine | | CAS: | 926304-76-9 | | MF: | C12H9BrN2O3 | | MW: | 309.12 | | EINECS: | | | Product Categories: | | | Mol File: | 926304-76-9.mol | ![5-Bromo-2-[(4-methoxycarbonyl)phenoxy]pyrimidine Structure](CAS/GIF/926304-76-9.gif) |
| | 5-Bromo-2-[(4-methoxycarbonyl)phenoxy]pyrimidine Chemical Properties |
| storage temp. | Sealed in dry,Room Temperature |
| | 5-Bromo-2-[(4-methoxycarbonyl)phenoxy]pyrimidine Usage And Synthesis |
| Synthesis | Methyl 4-hydroxybenzoate (260 mg, 1.71 mmol) was dissolved in N,N-dimethylformamide (DMF, 25 mL) at room temperature, followed by the addition of 60% sodium hydride (NaH, 75 mg, 1.9 mmol). The reaction mixture was stirred for 30 min. After that, 5-bromo-2-chloropyrimidine (300 mg, 1.55 mmol) was added and the reaction system was heated to 130 °C and the reaction was maintained for 0.5 hours. After standard post-treatment and purification steps, the target product methyl 4-(5-bromopyrimidin-2-yloxy)benzoate (428 mg, 89% yield) was obtained. | | References | [1] Patent: WO2007/22371, 2007, A2. Location in patent: Page/Page column 65 |
| | 5-Bromo-2-[(4-methoxycarbonyl)phenoxy]pyrimidine Preparation Products And Raw materials |
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