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Cefaclor monohydrate

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CAS:70356-03-5
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Cefaclor monohydrate manufacturers

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Cefaclor monohydrate Basic information
Product Name:Cefaclor monohydrate
Synonyms:(7R)-3-Chloro-7-[[(R)-aminophenylacetyl]amino]cepham-3-ene-4-carboxylic acid sodium salt;Muco-panoral;(6R,7R)-7-[[(2R)-2-amino-2-phenyl-acetyl]amino]-3-chloro-8-keto-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrate;(6R,7R)-7-[[(2R)-2-amino-2-phenylacetyl]amino]-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrate;(6R,7R)-7-[[(2R)-2-azanyl-2-phenyl-ethanoyl]amino]-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrate;Cefaclor (400 mg);5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 7-[[(2R)-2-aMino-2-phenylacetyl]aMino]-3-chloro-8-oxo-, hydrate (1:1),(6R,7R)-;CEFACLOR HYDRATE
CAS:70356-03-5
MF:C15H16ClN3O5S
MW:385.82
EINECS:641-991-5
Product Categories:Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;Chiral Reagents
Mol File:70356-03-5.mol
Cefaclor monohydrate Structure
Cefaclor monohydrate Chemical Properties
Melting point >180°C (dec.)
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility Slightly soluble in water, practically insoluble in methanol and in methylene chloride.
form Solid
color White to Light Beige
Major Applicationpharmaceutical (small molecule)
InChIInChI=1/C15H14ClN3O4S.H2O/c16-8-6-24-14-10(13(21)19(14)11(8)15(22)23)18-12(20)9(17)7-4-2-1-3-5-7;/h1-5,9-10,14H,6,17H2,(H,18,20)(H,22,23);1H2/t9-,10-,14-;/s3
InChIKeyWKJGTOYAEQDNIA-UZPHMIKQNA-N
SMILESO=C1[C@@H](NC(=O)[C@@H](C2C=CC=CC=2)N)[C@@]2([H])SCC(Cl)=C(C(=O)O)N12.O |&1:2,6,14,r|
CAS DataBase Reference70356-03-5(CAS DataBase Reference)
Safety Information
Hazard Codes Xn,Xi
Risk Statements 42/43-36
Safety Statements 22-36/37-45
WGK Germany 2
RTECS XI0363000
HS Code 2941906000
Storage Class11 - Combustible Solids
MSDS Information
Cefaclor monohydrate Usage And Synthesis
DescriptionCefaclor was found by Eli Lilly & Co. in 1976 in the course of studies on the improvement of synthetic procedures for cephalexin. The intermediates with chlorine at the 3 position of the cephem nucleus have excellent antibacterial activity. Cefaclor was selected from among the various derivatives that differed at the 7 position because of its strong activity and high bioavailability following oral administration.
Chemical PropertiesCrystalline Solid
UsesAntibacterial;Bacterial transpeptidase inhibitor
UsesSecond-generation cephalosporin antibiotic. Antibacterial.
Brand nameCeclor (Lilly); Raniclor (Ranbaxy).
Contact allergensCefaclor is a semisynthetic cephalosporin antibiotic, related to cefalexin, and a frequent inducer of serum sickness-like reactions.
Tag:Cefaclor monohydrate(70356-03-5) Related Product Information
ALTRENOGEST Tetraacetylethylenediamine N-ACETYL-L-TYROSINE ETHYL ESTER 4,4'-Diacetylbiphenyl MELIBIOSE Cephalexin Cefaclor Glycine 3,4'-DIAMINODIPHENYLMETHANE Cefadroxil D(-)-Phenylglycinamide 7-Amino-3-chloro cephalosporanic acid 2-Chloroethyl ethyl sulfide CIS-3-CHLOROACRYLIC ACID 2-Acetamidoacrylic acid 2-CHLOROETHYL METHYL SULFIDE Cefalexin Extend-release Tablet Cefaclor Dispensible Tablet

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