- Thio-NAD
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2026-09-15
- CAS:4090-29-3
- Min. Order: 1g
- Purity: 99.0%
- Supply Ability: 10kg/month
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| | Thionicotinamide adenine dinucleotide Basic information |
| Product Name: | Thionicotinamide adenine dinucleotide | | Synonyms: | THIONICOTINAMIDE ADENINE DINUCLEOTIDE;THIONICOTINAMIDE-DPN;adenosine 5'-(trihydrogen diphosphate), 5'->5'-ester with 3-(aminothioxomethyl)-1-beta-D-ribofuranosylpyridinium--ate;Thionicotinamide-NAD;beta-Thionicotinamide adenine dinucleotide, oxidised form 92+%;3-Thiocarbamoylpyridine adenine dinucleotide;3-Thionicotinamide adenine dinucleotide;Thino-Nicotinamide Adenine Dinuclotide | | CAS: | 4090-29-3 | | MF: | C21H27N7O13P2S | | MW: | 679.49 | | EINECS: | 223-828-6 | | Product Categories: | nucleoside | | Mol File: | 4090-29-3.mol |  |
| | Thionicotinamide adenine dinucleotide Chemical Properties |
| storage temp. | -20°C | | solubility | PBS (pH 7.2): 10 mg/ml | | form | powder to crystal | | color | Light orange to Yellow to Green | | InChIKey | DQRRIGAXTAXHLR-NNYOXOHSSA-N | | SMILES | O[C@@H]1[C@@H]([C@@H](COP(O)(=O)OP([O-])(=O)OC[C@@H]2[C@H]([C@@H](O)[C@H]([N+]3=CC=CC(C(=S)N)=C3)O2)O)O[C@H]1N1C=NC2C(=NC=NC1=2)N)O |&1:1,2,3,15,16,17,19,32,r| | | CAS DataBase Reference | 4090-29-3 |
| Hazard Codes | Xn | | Risk Statements | 20/21/22-36/37/38 | | Safety Statements | 26-36 | | WGK Germany | - | | HS Code | 29349990 | | Storage Class | 11 - Combustible Solids |
| | Thionicotinamide adenine dinucleotide Usage And Synthesis |
| Description | Thionicotinamide adenine dinucleotide is an analog of NAD. Use of Thio-NAD instead of NAD as a substrate for NAD(+)-consuming enzymes is more advantageous since the reduced form of Thio-NAD exhibits a substantial increase in absorbance at 405 nM, the most commonly available wavelength on microplate readers. | | Chemical Properties | Light yellow powder | | Uses | Thionicotinamide adenine dinucleotide has been used as a substrate analog in S-adenosyl-l-homocysteine (AdoHcy) hydrolases (SAHH) inhibition assay and in NAD+ glycohydrolase activity. | | Application | Thionicotinamide adenine dinucleotide (thio-NAD) is a NAD derivative used in the determination of Carnitine by an enzymic cycling method with carnitine dehydrogenase. | | Biochem/physiol Actions | Thionicotinamide adenine dinucleotide (sNAD) is an analog of coenzyme nicotinamide adenine dinucleotide (NAD) and NADH. sNAD is a potential inhibitor of NAD+ kinase. NAD+ kinase modulates NAD levels, contributing to cytotoxicity in cancer cells. | | storage | Transport product sealed, dry, and protected from light at ambient temperature. Store product dry and protected from light. For long term storage keep below -20℃. | | References | [1] SATOSHI WATABE. Ultrasensitive enzyme-linked immunosorbent assay (ELISA) of proteins by combination with the thio-NAD cycling method.[J]. Biophysics (Nagoya-shi, Japan), 2014, 10: 49-54. DOI: 10.2142/biophysics.10.49
[2] YUTA KYOSEI. Proposal of De Novo Antigen Test for COVID-19: Ultrasensitive Detection of Spike Proteins of SARS-CoV-2.[C]//10 8. 2020. DOI: 10.3390/diagnostics10080594
[3] WEN-HUNG WANG. A novel, rapid (within hours) culture-free diagnostic method for detecting live Mycobacterium tuberculosis with high sensitivity.[J]. EBioMedicine, 2020, 60: 103007. DOI: 10.1016/j.ebiom.2020.103007 |
| | Thionicotinamide adenine dinucleotide Preparation Products And Raw materials |
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