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Nicotinamide-N-oxide

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CAS:1986-81-8
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Products Intro: Product Name:Nicotinamide N-oxide
CAS:1986-81-8
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CAS:1986-81-8
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Nicotinamide-N-oxide manufacturers

  • Nicotinamide N-oxide
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  • $48.00 / 100mg
  • 2026-03-13
  • CAS:1986-81-8
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  • Purity: 99.66%
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  • Nicotinamide N-oxide
  • Nicotinamide N-oxide pictures
  • $48.00 / 100mg
  • 2026-03-13
  • CAS:1986-81-8
  • Min. Order:
  • Purity: 99.66%
  • Supply Ability: 10g
  • Nicotinamide N-oxide
  • Nicotinamide N-oxide pictures
  • $48.00 / 100mg
  • 2025-04-29
  • CAS:1986-81-8
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  • Purity: 99.9%
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Nicotinamide-N-oxide Basic information
Product Name:Nicotinamide-N-oxide
Synonyms:1-OXY-NICOTINAMIDE;3-(AMINOCARBONYL)PYRIDINIUM-1-OLATE;AKOS 94294;NICOTINAMIDE 1-OXIDE;NICOTINAMIDE N-OXIDE;TIMTEC-BB SBB004187;3-Pyridinecarboxamide, 1-oxide;3-Pyridinecarboxamide,1-oxide(9CI)
CAS:1986-81-8
MF:C6H6N2O2
MW:138.12
EINECS:217-859-4
Product Categories:Amines, Heterocycles, Metabolites & Impurities, Nicotine Derivatives, Nucleotides, Bases & Related Reagents;Amines;Bases & Related Reagents;Heterocycles;Metabolites & Impurities;Nicotine Derivatives;Nucleotides;AMIDE;Biochemicals and Reagents;NAD and Analogs;Nucleosides, Nucleotides, Oligonucleotides
Mol File:1986-81-8.mol
Nicotinamide-N-oxide Structure
Nicotinamide-N-oxide Chemical Properties
Melting point 291-293 °C (dec.)(lit.)
Boiling point 253.51°C (rough estimate)
density 1.3471 (rough estimate)
refractive index 1.5100 (estimate)
storage temp. Inert atmosphere,Room Temperature
solubility DMSO (Slightly, Heated), Methanol (Slightly, Heated)
pka14.38±0.50(Predicted)
form Solid
color White to Off-White
Sensitive Hygroscopic
Major Applicationpharmaceutical small molecule
InChI1S/C6H6N2O2/c7-6(9)5-2-1-3-8(10)4-5/h1-4H,(H2,7,9)
InChIKeyUSSFUVKEHXDAPM-UHFFFAOYSA-N
SMILESNC(=O)c1ccc[n+]([O-])c1
CAS DataBase Reference1986-81-8(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 3
HS Code 29339900
Storage Class11 - Combustible Solids
Hazard ClassificationsEye Irrit. 2
Skin Irrit. 2
STOT SE 3
MSDS Information
ProviderLanguage
3-(Aminocarbonyl)pyridinium-1-olate English
ACROS English
SigmaAldrich English
Nicotinamide-N-oxide Usage And Synthesis
DescriptionNicotinamide N-oxide is a metabolite of nicotinamide . It is formed via oxidation of nicotinamide by the cytochrome P450 (CYP) isoform CYP2E1. Nicotinamide N-oxide (30 mM) inhibits proliferation and induces reduction of nitroblue tetrazolium (NBT; ), indicating cell differentiation, in HL-60 promyelocytic leukemia cells. Urine levels of nicotinamide N-oxide are elevated in a mouse model of high-fat diet-induced obesity.
Chemical PropertiesWHITE TO SLIGHTLY YELLOW FLUFFY CRYST. NEEDLES
UsesA metabolite of Nicotinamide.
DefinitionChEBI: Nicotinamide N-oxide is a member of pyridines.
References[1] ALEXANDER MICHAEL REAL P P Shangyu Hong. Nicotinamide N-oxidation by CYP2E1 in human liver microsomes.[J]. Drug Metabolism and Disposition, 2013, 41 3: 550-553. DOI: 10.1124/dmd.112.049734
[2] KEIKO IWATA. Induction of differentiation in human promyelocytic leukemia HL-60 cell line by niacin-related compounds.[J]. Bioscience, Biotechnology, and Biochemistry, 2003, 67 5: 1132-1135. DOI: 10.1271/bbb.67.1132
[3] JEE-YOUN JUNG. 1H NMR-based metabolite profiling of diet-induced obesity in a mouse mode.[J]. BMB Reports, 2012, 45 7: 419-424. DOI: 10.5483/bmbrep.2012.45.7.248
Nicotinamide-N-oxide Preparation Products And Raw materials
Raw materialsAcetic acid-->Hydrogen peroxide-->Nicotinamide
Preparation ProductsForchlorfenuron-->2-Aminonicotinic acid-->2-Chloronicotinamide-->2-chloro-5-cyanopyridine
Tag:Nicotinamide-N-oxide(1986-81-8) Related Product Information
ETHYLENE OXIDE Nicotinamide NITRIC OXIDE Iron oxide Pyridinium chlorochromate Zinc oxide Magnesium oxide Propylene oxide Thionicotinamide (Diethoxymethyl)diphenylphosphine oxide Ethyl nicotinate Nicotinic acid β-Nicotinamide adenine dinucleotide Nicotinamide riboside MYRISTYL NICOTINATE Nicotinic Acid Riboside Benzyl nicotinate β-Nicotinamide Mononucleotide