8-OH-DPAT·hydrobromide

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8-OH-DPAT·hydrobromide manufacturers
8-OH-DPAT·hydrobromide Basic information
Product Name:8-OH-DPAT·hydrobromide
Synonyms:3-(Dipropylamino)tetralin-5-ol·hydrobrominate;Serotonin agonist DPAT;rac-8-Hydroxy-2-dipropylaMinotetralin HydrobroMide;(+/-)-8-Hydroxy(N,N-dipropyl-2-aMino)tetralin HydrobroMide;7-(DipropylaMino)-5,6,7,8-tetrahydro-1-naphthalenol HydrobroMide;8-OH-DPAT HRr;7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol hydrobromide;7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol hydrobromide76135-31-4
CAS:76135-31-4
MF:C16H25NO.BrH
MW:328.29
EINECS:
Product Categories:Agonist;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:76135-31-4.mol
8-OH-DPAT·hydrobromide Structure
8-OH-DPAT·hydrobromide Chemical Properties
Melting point 221.5-222.0 °C
storage temp. Desiccate at +4°C
solubility Soluble to 20 mM in water with gentle warming
form Powder
color White to off-white
EPA Substance Registry System1-Naphthalenol, 7-(dipropylamino)-5,6,7,8-tetrahydro-, hydrobromide (1:1) (76135-31-4)
Safety Information
HS Code 2921199990
MSDS Information
8-OH-DPAT·hydrobromide Usage And Synthesis
UsesDopamine receptor Agonist.
Biological ActivityThe standard selective 5-HT1A agonist. Also has moderate affinity for 5-HT7 receptors (pKi is 6.6 at the human 5-HT7 receptor expressed in HEK 293 cells). Reduces hippocampal 5-HT levels following systemic administration in rats in vivo.
in vivo

8-OH-DPAT (8-Hydroxy-DPAT) hydrobromide (32, 56, 80, 100 mg/kg; intramuscularly; 15 min prior to the testing session) of the highest dose significantly interferes with sustained attention and reinforcer efficacy (progressive ratio; PR) performance in the 3,4-methylenedioxymethamphetamine (MDMA)-exposed but not control animals[1].

IC 505-HT1A Receptor: 8.19 (pIC50)
storageDesiccate at +4°C
8-OH-DPAT·hydrobromide Preparation Products And Raw materials
Tag:8-OH-DPAT·hydrobromide(76135-31-4) Related Product Information
Bis(3-aminopropyl) ether S(-)-8-hydroxy-dpat hydrobromide (R)-(+)-8-Hydroxy-dpat hydrobromide 1,2,3,4-Tetrahydro-2-naphthylamine 5,6,7,8-Tetrahydro-1-naphthol Ortetamine AURORA KA-7111 1,2,3,4-Tetrahydro-N-methyl-2-naphthalenamine O-desmethylmethoxyphenamine 2-(2-aminoethyl)phenol 2-(2-aminopropyl)phenol 8-OH-DPAT·hydrobromide