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| (4R,6S)-6-[(1E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester Basic information |
Product Name: | (4R,6S)-6-[(1E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester | Synonyms: | (4R,6S)-6-[(1E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester;tert-Butyl(3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-isopropylidenedioxy-6-heptenoate;(3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluoro?phenyl)3-quinoline-base]-2,2-dimethyl-1,3-dioxane-6-heptene?acid?tert-butyl?ester;tert-butyl 2-((4R,6S);pitavastatin intermediate 3R5S isomer;2-[6-[2-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]ethenyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetic acid tert-butyl ester;3-dioxane-6-heptene?acid?tert-butyl?ester;6E)-7-[2-cyclopropyl-4-(4-fluoro?phenyl)3-quinoline-base]-2 | CAS: | 147489-06-3 | MF: | C32H36FNO4 | MW: | 517.63 | EINECS: | 1592732-453-0 | Product Categories: | | Mol File: | 147489-06-3.mol | ![(4R,6S)-6-[(1E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester Structure](CAS/GIF/147489-06-3.gif) |
| (4R,6S)-6-[(1E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester Chemical Properties |
Melting point | 105-116 °C(Solv: hexane (110-54-3)) | Boiling point | 604.6±55.0 °C(Predicted) | density | 1.184±0.06 g/cm3(Predicted) | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) | form | Solid | pka | 4.61±0.50(Predicted) | color | White to Off-White | InChIKey | GTJPCLUSFUIHTP-KAAYJFPCSA-N | SMILES | O1[C@H](/C=C/C2=C(C3=CC=C(F)C=C3)C3C(N=C2C2CC2)=CC=CC=3)C[C@H](CC(OC(C)(C)C)=O)OC1(C)C | CAS DataBase Reference | 147489-06-3 |
| (4R,6S)-6-[(1E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester Usage And Synthesis |
Uses | t-Butyl (3R,5S)-7-[2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-isopropylidenedioxy-6-heptenoate is an impurity from the synthesis of HMG-CoA reductase inhibitor Pitavastatin [P531040, (Z)-Pitavastatin Calcium Salt]. |
| (4R,6S)-6-[(1E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester Preparation Products And Raw materials |
Raw materials | D-erythro-Hexonic acid, 6-(2-benzothiazolylsulfonyl)-2,4,6-trideoxy-3,5-O-(1-methylethylidene)-, 1,1-dimethylethyl ester-->P-[[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]methyl]phosphonic acid diethyl ester-->tert-Butyl (4R-cis)-6-formaldehydel-2,2-dimethyl-1,3-dioxane-4-acetate-->2-Cyclopropyl-4-(4-fluorophenyl)quinoline-3-carboxaldehyde-->(4R-Cis)-6-Hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetic acid 1,1-dimethylethyl ester | Preparation Products | Pitavastatin calcium |
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