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| | (E)-3-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl-2-propenal Basic information |
| Product Name: | (E)-3-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl-2-propenal | | Synonyms: | (E)-3-[2-Cyclopropyl-4-(4-fluorophenyl)-3-Quinolinyl-2-propenal;PT-4;(E)-3-(2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)acrylaldehyde;(E)-3-[2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]prop-2-en-1-al;(E)-3''-[4-(4''-FLUOROPHENYL)-2-(CYCLOPROPYL)-3-QUINOLINYL]-2-PROPENAL;3-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl-2-propenal;2-Propenal, 3-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-, (2E)-;(E)-3-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl | | CAS: | 148901-68-2 | | MF: | C21H16FNO | | MW: | 317.36 | | EINECS: | | | Product Categories: | Pitavastatin Calcium Intermediates | | Mol File: | 148901-68-2.mol |  |
| | (E)-3-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl-2-propenal Chemical Properties |
| Melting point | 136-142 °C | | Boiling point | 491.8±45.0 °C(Predicted) | | density | 1.256±0.06 g/cm3(Predicted) | | pka | 3.82±0.50(Predicted) | | CAS DataBase Reference | 148901-68-2(CAS DataBase Reference) |
| | (E)-3-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl-2-propenal Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of (E)-3-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]acrolein from the compound (CAS: 113832-57-8) and 2-cyclopropyl-4-(4-fluorophenyl)quinoline-3-carboxaldehyde is as follows: the general procedure is as follows: except for the use of ethylidene cyclohexylamine (1.7 g, 13.8 mmol) in place of the ethylidene tert-butylamine (1.4 g, 14.1 mmol), the operation was the same as in Example 1. A portion of the reaction mixture was poured into 10% (w/v) aqueous acetic acid solution and analyzed by high performance liquid chromatography (HPLC) using the internal standard method. The analytical results showed that (E)-3-[4'-(4"-fluorophenyl)-2'-cyclopropylquinolin-3'-yl]propanal (1.7 g, 5.4 mmol, 78.3% yield) was successfully synthesized. | | References | [1] Patent: EP1614682, 2006, A1. Location in patent: Page/Page column 6 |
| | (E)-3-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl-2-propenal Preparation Products And Raw materials |
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