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- MPEG5-NHS
-
-
2026-08-03
- CAS:1449390-12-8
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1000kgs
- m-PEG6-NHS ester
-
-
2025-06-07
- CAS:1449390-12-8
- Min. Order: 1g
- Purity: >98.00%
- Supply Ability: 1g
|
| | MPEG5-NHS Basic information |
| Product Name: | MPEG5-NHS | | Synonyms: | MPEG5-NHS;4,7,10,13,16,19-Hexaoxaeicosanoic acid, 2,5-dioxo-1-pyrrolidinyl ester;mPEG5-CH2CH2COONHS Ester;Methyl-PEG5-NHS ester;mPEG5-SPA;mPEG5-CH2CH2COONHS/4,7,10,13,16,19-Hexaoxaeicosanoic acid, 2,5-dioxo-1-pyrrolidinyl ester;m-PEG6-NHS ester;mPEG6-NHS | | CAS: | 1449390-12-8 | | MF: | C18H31NO10 | | MW: | 421.44 | | EINECS: | | | Product Categories: | mPEG | | Mol File: | 1449390-12-8.mol |  |
| | MPEG5-NHS Chemical Properties |
| Boiling point | 502.6±60.0 °C(Predicted) | | density | 1.21±0.1 g/cm3(Predicted) | | storage temp. | Storage temp. 2-8°C | | solubility | Soluble in DMSO, DCM, DMF | | form | Liquid | | color | Colorless to light yellow |
| | MPEG5-NHS Usage And Synthesis |
| Description | m-PEG6-NHS ester is a PEG linker containing an NHS ester. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The hydrophilic PEG spacer increases solubility in aqueous media. | | Biological Activity | MPEG5-NHS is a non-cleavable 6-unit PEG-containing ADC linker for the synthesis of antibody drug conjugates (ADCs). It is a PROTAC linker belonging to the PEG/Alkyl/ether class, which can be used to synthesize PROTAC molecules. | | in vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. | | target | | PEGs | Alkyl/ether | Non-cleavable | |
| | MPEG5-NHS Preparation Products And Raw materials |
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