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| | 3-Cyano-2-fluoropyridine Basic information |
| | 3-Cyano-2-fluoropyridine Chemical Properties |
| Melting point | 27-30°C | | Boiling point | 214.6±20.0 °C(Predicted) | | density | 1.24±0.1 g/cm3(Predicted) | | Fp | 98℃ | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | -3.88±0.10(Predicted) | | form | powder to lump | | color | White to Dark green | | BRN | 386567 | | InChI | InChI=1S/C6H3FN2/c7-6-5(4-8)2-1-3-9-6/h1-3H | | InChIKey | USIDQCCXMGJOJM-UHFFFAOYSA-N | | SMILES | C1(F)=NC=CC=C1C#N | | CAS DataBase Reference | 3939-13-7(CAS DataBase Reference) |
| Hazard Codes | Xi,Xn | | Risk Statements | 20/21/22-36/37/38-5-36/38-22 | | Safety Statements | 26-36/37/39-36-24/25-23-3 | | RIDADR | 3276 | | WGK Germany | 3 | | Hazard Note | Harmful/Irritant | | HazardClass | 6.1 | | PackingGroup | III | | HS Code | 29333990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2 |
| | 3-Cyano-2-fluoropyridine Usage And Synthesis |
| Uses | 3-Cyano-2-fluoropyridine have been successfully used in preparation of compounds with diverse spectrum of biological activity. Other 3-cyano-2-fluoropyridine can potentially be used as promising agents for the positron emission tomography (PET). Additionally, it has previously been demonstrated that 3-cyanopyridines can be transformed into -amides, -carboxylic acids, and -esters. | | Synthesis | General method: 2-chloro-3-cyanopyridine (1.00 g, 6.76 mmol) was dissolved in DMSO (33.8 ml) at room temperature, followed by the addition of CsF (2.053 g, 13.51 mmol). The reaction mixture was stirred in air at 110 °C for 20 hours. After completion of the reaction, the reaction was quenched with water at room temperature and extracted with EtOAc. The organic layer was separated, washed sequentially with water and brine, dried over anhydrous Na2SO4 and subsequently concentrated under reduced pressure. Purification of the residue by column chromatography (silica gel as stationary phase and EtOAc in hexane as eluent) afforded 2-fluoro-3-cyanopyridine (0.639 g, 4.86 mmol, 71.9% yield) as a colorless oil. Compounds 3B'-8B' were prepared by a method similar to the synthetic procedure described above for 2B'. | | References | [1] European Journal of Inorganic Chemistry, 2017, vol. 2017, # 2, p. 330 - 339
[2] Tetrahedron Letters, 2015, vol. 56, # 44, p. 6043 - 6046
[3] Heterocycles, 1992, vol. 34, # 8, p. 1507 - 1510
[4] Organic Letters, 2015, vol. 17, # 8, p. 1866 - 1869
[5] Journal of Organic Chemistry, 2015, vol. 80, # 24, p. 12137 - 12145 |
| | 3-Cyano-2-fluoropyridine Preparation Products And Raw materials |
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