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4-Chloro-benzenesulfonic acid 5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylMethyl-tetrahydro-furan-3-ylMethyl ester

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4-Chloro-benzenesulfonic acid 5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylMethyl-tetrahydro-furan-3-ylMethyl ester Suppliers list
Company Name: ShenZhen H&D Pharmaceutical Technology Co., LTD
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Products Intro: Product Name:Posaconazole Impurity 106
CAS:175712-02-4
Purity:98% Package:10mg;|25mg;|50mg Remarks:spot supplies
Company Name: Capot Chemical Co.,Ltd.
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Products Intro: Product Name:[(3S,5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)tetrahydrofuran-3-yl]methyl 4-chlorobenzenesulfonate
CAS:175712-02-4
Purity:NLT 98% Package:1G;1KG;100KG
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Products Intro: Product Name:5-(2,4-Difluorophenyl)-5-(1,2,4-triazole-1-methyl)Tetrahydrofuran-3-methyl]p-Chlorobenzenesulfonate
CAS:175712-02-4
Purity:0.99 Package:5KG;1KG
Company Name: Beijing Cooperate Pharmaceutical Co.,Ltd
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Products Intro: Product Name:(3S-cis)-4-Chlorobenzenesulfonic acid [5-(2,4-difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)-3-furanyl]methyl ester
CAS:175712-02-4
Purity:98% Package:100G;1KG;5KG;10KG;25KG;50KG;100KG
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Products Intro: Product Name:4-Chloro-benzenesulfonic acid 5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylMethyl-tetrahydro-furan-3
CAS:175712-02-4
Purity:99% Package:25KG;5KG;1KG

4-Chloro-benzenesulfonic acid 5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylMethyl-tetrahydro-furan-3-ylMethyl ester manufacturers
4-Chloro-benzenesulfonic acid 5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylMethyl-tetrahydro-furan-3-ylMethyl ester Basic information
Product Name:4-Chloro-benzenesulfonic acid 5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylMethyl-tetrahydro-furan-3-ylMethyl ester
Synonyms:4-Chloro-benzenesulfonic acid 5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylMethyl-tetrahydro-furan-3-ylMethyl ester;(3S,5R)-5-(2,4-difluoro-phenyl)-5-1,2,4triazol-1-ylmethyl-tetrahydro-furan-3-ylmethyl 4-chlorobenzenesulfote;4-Chloro-benzenesulfonic acid 5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylMethyl-tetrahydro-furan-3-ylMethyl esterChemicalBook;4-Chloro-benzenesulfonic acid 5-(2;4-difluoro-phenyl)-5-[1;2,5-Anhydro-4-[[[(4-chlorophenyl)sulfonyl]oxy]methyl]-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-D-threo-pentitol;[(3S,5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)tetrahydrofuran-3-yl]methyl 4-chlorobenzenesulfonate 4-Chloro-benzenesulfonic acid;[(3S,5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)tetra hydrofuran-3-yl]methyl 4-chlorobenzenesulfonate
CAS:175712-02-4
MF:C20H18ClF2N3O4S
MW:469.89
EINECS:605-760-2
Product Categories:
Mol File:175712-02-4.mol
4-Chloro-benzenesulfonic acid 5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylMethyl-tetrahydro-furan-3-ylMethyl ester Structure
4-Chloro-benzenesulfonic acid 5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylMethyl-tetrahydro-furan-3-ylMethyl ester Chemical Properties
Boiling point 612.9±65.0 °C(Predicted)
density 1.49±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
pka2.75±0.10(Predicted)
AppearanceWhite to off-white Solid
InChIInChI=1S/C20H18ClF2N3O4S/c21-15-1-4-17(5-2-15)31(27,28)30-10-14-8-20(29-9-14,11-26-13-24-12-25-26)18-6-3-16(22)7-19(18)23/h1-7,12-14H,8-11H2/t14-,20-/m0/s1
InChIKeyWUPORSBDFSRGHD-XOBRGWDASA-N
SMILESC1(S(OC[C@H]2C[C@](CN3C=NC=N3)(C3=CC=C(F)C=C3F)OC2)(=O)=O)=CC=C(Cl)C=C1
CAS DataBase Reference175712-02-4
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MSDS Information
4-Chloro-benzenesulfonic acid 5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylMethyl-tetrahydro-furan-3-ylMethyl ester Usage And Synthesis
UsesThe main ring of posaconazole can be used to synthesize the antifungal drug itraconazole.
Synthesis

Schering-Plough disclosed the synthetic route to the main ring of posaconazole in 1995 in US5661151A, which uses 2'-chloro-2,4-difluoroacetophenone as a starting material, and a Wittig reaction, a flip of the configuration, to end up with the end product.

4-Chloro-benzenesulfonic acid 5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylMethyl-tetrahydro-furan-3-ylMethyl ester Preparation Products And Raw materials
Tag:4-Chloro-benzenesulfonic acid 5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylMethyl-tetrahydro-furan-3-ylMethyl ester(175712-02-4) Related Product Information
2-[(1S,2S)-1-ethyl-2-bezyloxypropyl]-2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]- 3H-1,2,4-Triazol-3-one 3-(2',4'-DIFLUOROBENZOYL)PROPIONIC ACID N'-((2S,3S)-2-(Benzyloxy)pentan-3-yl)formohydrazide oxalate (5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester 3-Pentanone, 2-(phenylMethoxy)-, (2S)- (Related Reference) D-threo-Pentitol, 2,5-anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-(hydroxyMethyl)-1-(1H-1,2,4-triazol-1-yl)- 1,3-PROPANEDIOL, 2-[2-(2,4-DIFLUOROPHENYL)-2-PROPEN-1-YL]- Posaconazole Posaconazole DiastereoisoMer interMediate 5 Toluene-4-sulfonic acid 5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylMethyl-tetrahydro-furan-3-ylMethyl Posaconazole Impurity 48 4-(4-(4-(4-(((3S,5S)-5-((1H-1,2,4-triazol-1-yl)Methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)Methoxy)phenyl)piperazin-1-yl)phenyl)-1-((2S,3S)-2-hydroxypentan-3-yl)-1H-1,2,4-triazol-5(4H)-one Posaconazole Impurity 49 [(2S,3S)-2-(benzyloxy)pentan-3-yl]hydrazine 2-[(1S,2S)-1-Ethyl-2-(phenylmethoxy)propyl]hydrazinecarboxaldehyde 1-(4-Aminophenyl)-4-(4-hydroxyphenyl)piperazine Phenyl (4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)carbamate