BOC-LYS-OTBU manufacturers
- boc-lys-otbu
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- $1.10
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2026-07-02
- CAS:7750-42-7
- Min. Order: 1KG
- Purity: 99%min
- Supply Ability: 100KG
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| | BOC-LYS-OTBU Basic information |
| Product Name: | BOC-LYS-OTBU | | Synonyms: | tert-butyl (2S)-6-amino-2-{[(tert-butoxy)carbonyl]amino}hexanoate;(S)-tert-Butyl 6-amino-2-((tert-butoxycarbonyl)amino)hexanoate;(Tert-Butoxy)Carbonyl Lys-OtBu (Syrup);tert-butyl N-tert-butyloxycarbonyl-L-lysinate;Boc-Lys-OtBu (Syrup);L-Lysine, N2-[(1,1-dimethylethoxy)carbonyl]-, 1,1-dimethylethyl ester;N-Boc-Lysine Tert-butyl Ester;N2-Boc-L-lysine tert-butyl ester | | CAS: | 7750-42-7 | | MF: | C15H30N2O4 | | MW: | 302.41 | | EINECS: | | | Product Categories: | | | Mol File: | 7750-42-7.mol |  |
| | BOC-LYS-OTBU Chemical Properties |
| Boiling point | 406.7±40.0 °C(Predicted) | | density | 1.021±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C(protect from light) | | solubility | Chloroform (Sparingly), Methanol (Sparingly) | | pka | 11.16±0.46(Predicted) | | form | Solid | | color | Off-White | | Optical Rotation | 7.867°(C=0.01g/ml CHCL3) | | InChI | InChI=1S/C15H30N2O4/c1-14(2,3)20-12(18)11(9-7-8-10-16)17-13(19)21-15(4,5)6/h11H,7-10,16H2,1-6H3,(H,17,19)/t11-/m0/s1 | | InChIKey | LVUBESNUUMLEHL-NSHDSACASA-N | | SMILES | C(OC(C)(C)C)(=O)[C@H](CCCCN)NC(OC(C)(C)C)=O |
| | BOC-LYS-OTBU Usage And Synthesis |
| Uses | N-Boc-Lysine Tert-butyl Ester is used in preparation of Tetrahydroisoquinoline derivatives as blood coagulation factor inhibitors useful in the treatment of thromboembolic disorders. | | Synthesis | General procedure for the synthesis of (S)-6-amino-2-((tert-butoxycarbonyl)amino)hexanoic acid tert-butyl ester from (S)-6-(((benzyloxy)carbonyl)amino)-2-((tert-butoxycarbonyl)amino)hexanoic acid tert-butyl ester: (0133) (0134) (S)-6-(((benzyloxy)carbonyl)amino)-2-((tert-butoxycarbonyl)amino)hexanoic acid tert-butyl ester was butyl ester (98.8 mg, 0.226 mmol) and 10% Pd/C (12.1 mg, 11.4 μmol) were dissolved in methanol (1 mL) and stirred for 2 h at room temperature in a hydrogen atmosphere. Upon completion of the reaction, the solid catalyst was removed by diatomaceous earth filtration and the filtrate was concentrated under reduced pressure to afford tert-butyl (S)-6-amino-2-((tert-butoxycarbonyl)amino)hexanoate in 96% (66.1 mg) yield. The resulting product was used directly in the next reaction without further purification. | | References | [1] Angewandte Chemie - International Edition, 2009, vol. 48, # 9, p. 1633 - 1635
[2] Patent: EP2952504, 2015, A1. Location in patent: Paragraph 0133-0134
[3] Tetrahedron Letters, 2014, vol. 55, # 46, p. 6343 - 6346
[4] Journal of Agricultural and Food Chemistry, 2018, vol. 66, # 15, p. 3957 - 3965
[5] Journal of the American Chemical Society, 1997, vol. 119, # 17, p. 4086 - 4087 |
| | BOC-LYS-OTBU Preparation Products And Raw materials |
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