- 3-Aminoisonicotinic acid
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- $15.00 / 1KG
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2021-08-12
- CAS:7579-20-6
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
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| | 3-Aminoisonicotinic acid Basic information |
| | 3-Aminoisonicotinic acid Chemical Properties |
| Melting point | 300°C | | Boiling point | 497.1±30.0 °C(Predicted) | | density | 1.417±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | Water | | pka | 2.69±0.10(Predicted) | | form | Solid | | color | Yellow to Brown | | InChI | 1S/C6H6N2O2/c7-5-3-8-2-1-4(5)6(9)10/h1-3H,7H2,(H,9,10) | | InChIKey | FYEQKMAVRYRMBL-UHFFFAOYSA-N | | SMILES | Nc1cnccc1C(O)=O | | CAS DataBase Reference | 7579-20-6(CAS DataBase Reference) | | NIST Chemistry Reference | 4-Pyridinecarboxylic acid, 3-amino-(7579-20-6) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-37/39 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 29333990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Provider | Language |
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ALFA
| English |
| | 3-Aminoisonicotinic acid Usage And Synthesis |
| Chemical Properties | Light yellow Cryst | | Uses | 3-Aminoisonicotinic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | | Synthesis | The general procedure for the synthesis of 3-aminoisonicotinic acid from 3,4-pyridinedicarboximide is as follows:
Step 1: Bromine (1.93 mL, 38.6 mmol) was slowly added to a 10% aqueous sodium hydroxide solution (100 mL) followed by 1H-pyrrolo[3,4-c]pyridine-1,3(2H)-dione (5.20 g, 35.1 mmol) under ice-bath cooling conditions. Next, 10% aqueous sodium hydroxide solution (60 mL) was added to the reaction mixture and the mixture was heated and stirred at 90 °C for 40 min. Upon completion of the reaction, the mixture was cooled to room temperature and the pH was adjusted with 50% sulfuric acid to 3. The precipitated solid was collected by filtration and washed with water to afford 3-aminoisonicotinic acid in the form of a light yellow powder (5.00 g, 100% yield). The product was characterized by 1H-NMR (200 MHz, DMSO-d6): δ 7.46 (1H, d, J = 5.1 Hz), 7.73 (1H, d, J = 5.1 Hz), 8.21 (1H, s). | | References | [1] Patent: US2015/329556, 2015, A1. Location in patent: Paragraph 1612-1614
[2] Bioorganic and Medicinal Chemistry, 2001, vol. 9, # 8, p. 2061 - 2071
[3] Australian Journal of Chemistry, 1993, vol. 46, # 7, p. 987 - 993
[4] Tetrahedron Letters, 1993, vol. 34, # 39, p. 6225 - 6228
[5] Patent: US2006/199804, 2006, A1. Location in patent: Page/Page column 29 |
| | 3-Aminoisonicotinic acid Preparation Products And Raw materials |
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