苦参醇C
| 中文名称 | 苦参醇C |
|---|---|
| 中文同义词 | 苦参醇C;苦参新醇 C |
| 英文名称 | Kushenol C |
| 英文同义词 | Kushenol C;2-(2,4-Dihydroxyphenyl)-3,5,7-trihydroxy-8-[(2R)-5-methyl-2-(1-methylethenyl)-4-hexenyl]-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-8-[(2R)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]- |
| CAS号 | 99119-73-0 |
| 分子式 | C25H26O7 |
| 分子量 | 438.47 |
| EINECS号 | |
| 相关类别 | 中药对照品;标准品 -中药标准品;标准品 |
| Mol文件 | 99119-73-0.mol |
| 结构式 |  |
苦参醇C 性质
| 溶解度 | 溶于氯仿、二氯甲烷、乙酸乙酯、DMSO、丙酮等。 |
|---|---|
| 形态 | 粉末 |
| 颜色 | 粘黄色 |
Kushenol C dose-dependently suppresses the production of inflammatory mediators, including NO, PGE2, IL-6, IL1β, MCP-1, and IFN-β in LPS-stimulated RAW264.7 macrophages. Kushenol C (50-100 µM;) significantly decreases the phosphorylation of both STAT1 molecules and STAT6 in a dose-dependent manner in LPS-stimulated RAW264.7 cells.
Kushenol C upregulates the expression of HO-1 and its activities in the LPS-stimulated RAW264.7 macrophages. In HaCaT cells, Kushenol C prevents DNA damage and cell death by upregulating the endogenous antioxidant defense system involving glutathione, superoxide dismutase, and catalase, which prevents reactive oxygen species production from tert-butyl hydroperoxide (tBHP)-induced oxidative stress in HaCaT cells.
Kushenol C inhibits BChE and AChE with IC
50
s of 54.86 and 33.13 µM.