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1-Cyclohexylpiperazine

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1-Cyclohexylpiperazine Basic information
Product Name:1-Cyclohexylpiperazine
Synonyms:N-Cyclohexylpiperazine;BUTTPARK 82\06-06;1-CYCLOHEXYL-PIPERAZINE >98%;1-CYCLOHEXYLPIPERAZINE 98%;1-Cyclohexylpiperizine;Piperazine, 1-cyclohexyl-;AKOS BBS-00003612;1-Cyclohexylpiperazine ,97%
CAS:17766-28-8
MF:C10H20N2
MW:168.28
EINECS:241-750-0
Product Categories:Building Blocks;Heterocyclic Building Blocks;Piperazines;Amines and Anilines;Intermediate;1
Mol File:17766-28-8.mol
1-Cyclohexylpiperazine Structure
1-Cyclohexylpiperazine Chemical Properties
Melting point 28-32 °C
Boiling point 287.25°C (rough estimate)
density 0.9725 (rough estimate)
refractive index 1.6011
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility Chloroform (Slightly), Methanol (Slightly)
form Low Melting Solid
pka9.25±0.10(Predicted)
color Yellow-brownish
BRN 106845
InChIInChI=1S/C10H20N2/c1-2-4-10(5-3-1)12-8-6-11-7-9-12/h10-11H,1-9H2
InChIKeyXPDSXKIDJNKIQY-UHFFFAOYSA-N
SMILESN1(C2CCCCC2)CCNCC1
CAS DataBase Reference17766-28-8(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 24/25-26
WGK Germany 3
Hazard Note Irritant
HS Code 29335990
MSDS Information
ProviderLanguage
1-Cyclohexylpiperazine English
ACROS English
1-Cyclohexylpiperazine Usage And Synthesis
Chemical Propertiesyellow-brownish low melting solid
Uses1-Cyclohexylpiperazine is an σ1 and σ2 receptor ligands with diagnostic and therapeutic potentials.
Synthesis Reference(s)Tetrahedron Letters, 35, p. 7331, 1994 DOI: 10.1016/0040-4039(94)85306-1
Materials Uses1-Cyclohexylpiperazine can be used to develop new luminescent materials such as [CYP]ZnBr4 (CYP = 1-cyclohexylpiperazine). It is a highly efficient blue luminescent lead-free halide material with high luminous efficiency (photoluminescence quantum yield up to 79.22%) and stability, which can be used to manufacture highly efficient blue phosphors for white light-emitting diodes (LEDs) [1].
Synthesis
tert-butyl 4-cyclohexylpiperazine-1-carboxylate

1224935-95-8

1-Cyclohexylpiperazine

17766-28-8

General procedure for the synthesis of 1-cyclohexylpiperazine from tert-butyl 4-cyclohexylpiperazine-1-carboxylate: tert-butyl 4-cyclohexylpiperazine-1-carboxylate (1.38 g, 5.15 mmol) was dissolved in a mixture of ethanol/hydrochloric acid (15 mL), and the reaction was stirred for 18 h at room temperature. After completion of the reaction, the solvent was removed by distillation under reduced pressure. To the residue, 5 mL of water was added and the aqueous phase was washed with ethyl acetate (5 mL × 3). Subsequently, the aqueous phase was adjusted to pH 7~8 with base and extracted with ethyl acetate (10 mL × 3). All organic phases were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to give 0.78 g of 1-cyclohexylpiperazine (confirmed by LC-MS and TLC, yield: 90.1%).

References[1] Wang, Yu-Yin et al. “High Emission Efficiency and Thermal Stability in Zero-Dimensional Hybrid Zinc Halide as a Blue Light Emitter.” Inorganic chemistry vol. 62,38 (2023): 15711-15718. doi:10.1021/acs.inorgchem.3c02313
Tag:1-Cyclohexylpiperazine(17766-28-8) Related Product Information
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