1-((4-cyano-4-(pyridin-2-yl)piperidin-1-yl)methyl)-4-oxo-4H-quinolizine-3-carboxylic acid

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1-((4-cyano-4-(pyridin-2-yl)piperidin-1-yl)methyl)-4-oxo-4H-quinolizine-3-carboxylic acid manufacturers

  • PQCA
  • PQCA pictures
  • $47.00
  • 2026-07-14
  • CAS:1144504-35-7
  • Purity: 99.88%
  • Supply Ability: 10g
  • PQCA
  • PQCA pictures
  • $47.00
  • 2026-07-14
  • CAS:1144504-35-7
  • Purity: 99.88%
  • Supply Ability: 10g
1-((4-cyano-4-(pyridin-2-yl)piperidin-1-yl)methyl)-4-oxo-4H-quinolizine-3-carboxylic acid Basic information
Product Name:1-((4-cyano-4-(pyridin-2-yl)piperidin-1-yl)methyl)-4-oxo-4H-quinolizine-3-carboxylic acid
Synonyms:1-((4-cyano-4-(pyridin-2-yl)piperidin-1-yl)methyl)-4-oxo-4H-quinolizine-3-carboxylic acid;PQCA;4H-Quinolizine-3-carboxylic acid, 1-[[4-cyano-4-(2-pyridinyl)-1-piperidinyl]methyl]-4-oxo-;PQCA, 10 mM in DMSO;MSD-M1PAM
CAS:1144504-35-7
MF:C22H20N4O3
MW:388.42
EINECS:
Product Categories:
Mol File:1144504-35-7.mol
1-((4-cyano-4-(pyridin-2-yl)piperidin-1-yl)methyl)-4-oxo-4H-quinolizine-3-carboxylic acid Structure
1-((4-cyano-4-(pyridin-2-yl)piperidin-1-yl)methyl)-4-oxo-4H-quinolizine-3-carboxylic acid Chemical Properties
Boiling point 708.5±60.0 °C(Predicted)
density 1.41±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 10 mg/mL (25.75 mM; ultrasonic and warming and heat to 80°C)
form Solid
pka1.83±0.20(Predicted)
color White to yellow
Safety Information
MSDS Information
1-((4-cyano-4-(pyridin-2-yl)piperidin-1-yl)methyl)-4-oxo-4H-quinolizine-3-carboxylic acid Usage And Synthesis
UsesPQCA is a highly selective and potent muscarinic M1 receptor positive allosteric modulator. PQCA is a novel M1 muscarinic potentiator that improves cognition without adverse effects compared to donepezil and xanomeline in rhesus monkey.
in vivo

PQCA (3-30 mg/kg; oral administration; single- or pair-housed male rhesus monkeys) treatment attenuates the scopolamine deficits in PAL and CPT tasks. Blockade of muscarinic signaling by scopolamine produces significant impairments in both tasks[1].

Animal Model:Ten single- or pair-housed male rhesus monkeys (6-10 years old; 5.2-10.5 kg) with scopolamine[1]
Dosage:3 mg/kg, 10 mg/kg, or 30 mg/kg
Administration:Oral administration
Result:Attenuated the scopolamine deficits in paired-associates learning (PAL) and the continuous-performance task (CPT).
1-((4-cyano-4-(pyridin-2-yl)piperidin-1-yl)methyl)-4-oxo-4H-quinolizine-3-carboxylic acid Preparation Products And Raw materials
Tag:1-((4-cyano-4-(pyridin-2-yl)piperidin-1-yl)methyl)-4-oxo-4H-quinolizine-3-carboxylic acid(1144504-35-7) Related Product Information
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