- Propargyl-PEG10-PA
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2026-07-24
- CAS:2055022-18-7
- Min. Order: 1g
- Purity: 98%
- Supply Ability: 1g/bottle, 10g/bottle, 100g/bottle
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| | Propargyl-PEG10-acid Basic information |
| Product Name: | Propargyl-PEG10-acid | | Synonyms: | Propargyl-PEG10-acid;Propargyl-PEG9-CH2CH2COOH;3-[2-[2-[2-[2-[2-[2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid;CAS_2055022-18-7;4,7,10,13,16,19,22,25,28,31-Decaoxatetratriacont-33-ynoic acid;Propargyl-PEG9-CH2CH2COOH/4,7,10,13,16,19,22,25,28,31-Decaoxatetratriacont-33-ynoic acid;Propargyl-PEG9-C2-COOH;Propargyl-PEG10-PA | | CAS: | 2055022-18-7 | | MF: | C24H44O12 | | MW: | 524.6 | | EINECS: | | | Product Categories: | | | Mol File: | 2055022-18-7.mol |  |
| | Propargyl-PEG10-acid Chemical Properties |
| Boiling point | 593.9±50.0 °C(Predicted) | | density | 1.124±0.06 g/cm3(Predicted) | | storage temp. | Store at Room Tem. | | solubility | Soluble in Water, DMSO, DCM, DMF | | pka | 4.28±0.10(Predicted) | | form | Liquid
(Density: 1.124±0.06 g/cm3) | | color | Colorless to light yellow |
| | Propargyl-PEG10-acid Usage And Synthesis |
| Description | Propargyl-PEG10-acid is a propargyl PEG linker with a terminal carboxylic acid. The terminal carboxylic acid forms amide bonds with primary amines; activators (EDC or HATU) will be needed. The propargyl group can react with azide-bearing compounds to form stable triazole bonds. | | Uses | Propargyl-PEG10-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG10-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Propargyl-PEG10-acid Preparation Products And Raw materials |
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