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| | Propargyl-PEG2-methylamine Basic information |
| Product Name: | Propargyl-PEG2-methylamine | | Synonyms: | Propargyl-PEG2-methylamine;Propargyl-PEG2-NHMe;Ethanamine, N-methyl-2-[2-(2-propyn-1-yloxy)ethoxy]-;Propargyl-PEG2-NHMe/Ethanamine, N-methyl-2-[2-(2-propyn-1-yloxy)ethoxy]- | | CAS: | 1835759-76-6 | | MF: | C8H15NO2 | | MW: | 157.21 | | EINECS: | | | Product Categories: | | | Mol File: | 1835759-76-6.mol |  |
| | Propargyl-PEG2-methylamine Chemical Properties |
| Boiling point | 214.6±20.0 °C(Predicted) | | density | 0.947±0.06 g/cm3(Predicted) | | solubility | Soluble in Water, DMSO, DCM, DMF | | pka | 9.50±0.10(Predicted) |
| | Propargyl-PEG2-methylamine Usage And Synthesis |
| Description | Propargyl-PEG2-methylamine is a crosslinker with a propargyl group and methylamine group. The propargyl group forms triazole linkage with azide-bearing compounds or biomolecules in copper catalyzed Click Chemistry reactions. The methylamine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. | | Uses | Propargyl-PEG2-methylamine (Propargyl-PEG2-NHMe) is a PEG derivative containing a propargyl group and methylamine group. Propargyl-PEG2-methylamine is an PROTAC linker used in the synthesis of PROTACs. Propargyl-PEG2-methylamine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups[1]. | | References | [1] Wurz RP, et al. A "Click Chemistry Platform" for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation. J Med Chem. 2018 Jan 25;61(2):453-461. DOI:10.1021/acs.jmedchem.6b01781 |
| | Propargyl-PEG2-methylamine Preparation Products And Raw materials |
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