- Propargyl-PEG1-PA
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- $0.00 / 1g
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2026-02-05
- CAS:55683-37-9
- Min. Order: 1g
- Purity: 98%
- Supply Ability: 1g/bottle, 10g/bottle, 100g/bottle
- Propargyl-PEG1-acid
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- $0.00 / 100mg
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2026-01-05
- CAS:55683-37-9
- Min. Order:
- Purity:
- Supply Ability: 10g
- Propargyl-PEG1-acid
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- $0.00 / 5g
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2025-06-07
- CAS:55683-37-9
- Min. Order: 5g
- Purity: >98.00%
- Supply Ability: 5g
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| | 3-(2-Propynyloxy)propanoic acid Basic information |
| Product Name: | 3-(2-Propynyloxy)propanoic acid | | Synonyms: | 3-(2-Propyn-1-yloxy)propanoic acid;3-(Prop-2-yn-1-yloxy)propanoic acid;3-(2-Propynyloxy)propanoic acid;3-(prop-2-ynyloxy)propanoic acid;Propargyl-PEG1-Acid;Propanoic acid, 3-(2-propyn-1-yloxy)-;Propargyl-PEG1-acid >=95%;Alkyne-PEG1-COOH | | CAS: | 55683-37-9 | | MF: | C6H8O3 | | MW: | 128.13 | | EINECS: | | | Product Categories: | peg | | Mol File: | 55683-37-9.mol |  |
| | 3-(2-Propynyloxy)propanoic acid Chemical Properties |
| Boiling point | 265.8±20.0 °C(Predicted) | | density | 1.140±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | form | Liquid | | pka | 4.19±0.10(Predicted) | | color | Colorless to light yellow | | InChI | InChI=1S/C6H8O3/c1-2-4-9-5-3-6(7)8/h1H,3-5H2,(H,7,8) | | InChIKey | GMFDYXLFHSFUHE-UHFFFAOYSA-N | | SMILES | C(O)(=O)CCOCC#C |
| WGK Germany | WGK 3 | | Storage Class | 10 - Combustible liquids |
| | 3-(2-Propynyloxy)propanoic acid Usage And Synthesis |
| Description | Propargyl-PEG1-acid is a crosslinker with a propargyl group and a carboxylic acid group. The carboxylic acid reacts with primary amine under the activation of HATU or EDC. The propargyl group can participate in copper catalyzed azide-alkyne Click Chemistry reactions. | | Uses | This is a crosslinker with an alkyne group on one end and a carboxyl group on the other end. The alkyne can be used to attach to an azide using copper-catalyzed click chemistry. The compound contains a single PEG unit to help improve solubility. | | reaction suitability | reagent type: linker | | Synthesis | General procedure for the synthesis of propargyl-monoethylene glycol-carboxylic acid from tert-butyl 3-(prop-2-yn-1-yloxy)propionate: trifluoroacetic acid (8.065 mL, 108.6 mmol) was added to a solution of tert-butyl 3-(prop-2-yn-1-yloxy)propionate (2.0 g, 10.86 mmol) in dichloromethane (50 mL). The reaction mixture was stirred overnight at room temperature and subsequently concentrated under vacuum, co-evaporated with toluene and purified by fast chromatography on 80 g silica gel (using a dichloromethane/methanol gradient elution) to afford 1.1 g of propargyl-monoethyleneglycol-carboxylic acid as an oil (80% yield).1H NMR (400 MHz, DMSO-d6, δ, ppm): 2.46 (t J = 6.4 Hz, 2H); 3.43 (t, J = 2.4 Hz, 1H); 3.63 (t, J = 6.4 Hz, 2H); 4.11 (d, J = 2.4 Hz, 2H); 12.20 (broad peak, 1H). | | IC 50 | PEGs | | References | [1] Patent: WO2017/76998, 2017, A1. Location in patent: Page/Page column 222-223
[2] Israel Journal of Chemistry, 2001, vol. 41, # 4, p. 283 - 295 |
| | 3-(2-Propynyloxy)propanoic acid Preparation Products And Raw materials |
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