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| | Propargyl-PEG4-methylamine Basic information |
| | Propargyl-PEG4-methylamine Chemical Properties |
| Boiling point | 317.1±32.0 °C(Predicted) | | density | 1.002±0.06 g/cm3(Predicted) | | solubility | Soluble in Water, DMSO, DMF, DCM | | pka | 9.52±0.10(Predicted) |
| | Propargyl-PEG4-methylamine Usage And Synthesis |
| Description | Propargyl-PEG4-methylamine is a PEG linker that can be react with azide compounds in copper catalyzed azide-alkyne Click Chemistry reactions. The methylamine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The PEG spacer increases hydrophilicity of the linker in aqueous environment. | | Uses | Propargyl-PEG4-methylamine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG4-methylamine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Propargyl-PEG4-methylamine Preparation Products And Raw materials |
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