N3-PEG5-CH2CO2-NHS manufacturers
- N3-PEG5-CH2COO-NHS
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2026-07-24
- CAS:2144777-77-3
- Min. Order: 1g
- Purity: 98%
- Supply Ability: 1g/bottle, 10g/bottle, 100g/bottle
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| | N3-PEG5-CH2CO2-NHS Basic information |
| Product Name: | N3-PEG5-CH2CO2-NHS | | Synonyms: | AZIDO-PEG5-CH2CO2-NHS;N3-PEG5-CH2CO2-NHS;N3-PEG5-CH2COONHS;Azido-PEG5-CH2COOH NHS Ester;N3-PEG5-SCM;N3-PEG5-CH2COONHS/Acetic acid, 2-[(14-azido-3,6,9,12-tetraoxatetradec-1-yl)oxy]-, 2,5-dioxo-1-pyrrolidinyl ester;Azido-PEG5-CH2COO-NHS ester | | CAS: | 2144777-77-3 | | MF: | C16H26N4O9 | | MW: | 418.4 | | EINECS: | | | Product Categories: | peg | | Mol File: | 2144777-77-3.mol |  |
| | N3-PEG5-CH2CO2-NHS Chemical Properties |
| storage temp. | -20°C, sealed storage, away from moisture | | solubility | Soluble in DMSO, DCM, DMF | | form | Liquid | | color | Colorless to light yellow |
| | N3-PEG5-CH2CO2-NHS Usage And Synthesis |
| Description | Azido-PEG5-CH2CO2-NHS is a very active pegylation reagent with 5 PEG units. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group allows the reaction with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. | | Uses | Azido-PEG5-CH2CO2-NHS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG5-CH2CO2-NHS is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | N3-PEG5-CH2CO2-NHS Preparation Products And Raw materials |
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