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| | 3,3'-Dimethoxybenzidine dihydrochloride Basic information |
| Product Name: | 3,3'-Dimethoxybenzidine dihydrochloride | | Synonyms: | 3,3’-dimethoxy-4,4’-diaminobiphenyldihydrochloride;3,3’-dimethoxy-benzidindihydrochloride;3,3-dimethoxybiphenyl-4,4-ylenediammonium dichloride;ortho-dianisidine dihydrochloride;O-DIANISIDINE DIHYDROCHLORIDE 10 MG*TABL ETS, TRU-ME;3,3'-DIMETHOXYBENZIDINE HYDROCHLORIDE HY DRATE;3,3'-DIMETHOXYBENZIDINE DIHYDROCHLORIDE, PGE WITH 50 TABL.;2-Dianisidinedi2HCl | | CAS: | 20325-40-0 | | MF: | C14H17ClN2O2 | | MW: | 280.75 | | EINECS: | 243-737-5 | | Product Categories: | Biphenyl & Diphenyl ether | | Mol File: | 20325-40-0.mol |  |
| | 3,3'-Dimethoxybenzidine dihydrochloride Chemical Properties |
| Melting point | 268 °C | | Fp | 206℃ | | storage temp. | 2-8°C | | solubility | H2O: soluble25mg/mL | | form | tablet | | color | Light beige to purple-gray | | PH | 1.7 at 20℃ and 100g/L | | Water Solubility | 1-5 g/100 mL at 20 ºC | | BRN | 3917996 | | Major Application | diagnostic assay manufacturing
hematology
histology | | InChI | InChI=1S/C14H16N2O2.ClH/c1-17-13-7-9(3-5-11(13)15)10-4-6-12(16)14(8-10)18-2;/h3-8H,15-16H2,1-2H3;1H | | InChIKey | UXTIAFYTYOEQHV-UHFFFAOYSA-N | | SMILES | O(C1=C(C=CC(C2C=CC(N)=C(OC)C=2)=C1)N)C.Cl | | CAS DataBase Reference | 20325-40-0(CAS DataBase Reference) | | EPA Substance Registry System | 3,3'-Dimethoxybenzidine dihydrochloride (20325-40-0) |
| Hazard Codes | T | | Risk Statements | 45-22 | | Safety Statements | 53-45 | | RIDADR | 2811 | | WGK Germany | 3 | | RTECS | DD1050000 | | TSCA | TSCA listed | | HazardClass | 6.1(a) | | PackingGroup | II | | HS Code | 29222990 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 4 Oral
Carc. 1B
Eye Dam. 1
Skin Corr. 1 |
| | 3,3'-Dimethoxybenzidine dihydrochloride Usage And Synthesis |
| Description | o-Dianisidine (dihydrochloride) is a colorimetric peroxidase substrate that has been used as a substrate to semi-quantitatively measure lactate, uric acid , and glucose. It has also been used as a reagent for the detection of various metals, thiocyanates, and nitrites. This aromatic amine is initially colorless but turns to violet upon oxidization and is spectrophotometrically measured at a wavelength of 405 nm. | | Chemical Properties | Off-white or grey tablets | | Uses | o-Dianisidine (3,3′-dimethoxybenzidine) has been used as a component of GO (glucose oxidase) reagent, which is used for measuring the glucose content. It has also been used as a substrate to measure myeloperoxidase activity. | | Uses | It is suitable for use in ELISA procedures. In neurohistochemistry o-Dianisidine dihydrochloride has demonstrated perikaryal labeling as well as retrograde and anterograde transport to the primary olfactory cortex. It has also been used for a paper based-micro fluidic device to semi-quantitatively measure lactate, uric acid, and glucose. 3,3'-Dimethoxybenzidine is used principally as an intermediate in the production of commercial bisazobiphenyl dyes for coloring textiles, paper, plastic, rubber, and leather. | | General Description | Off-white powder. | | Air & Water Reactions | Water soluble. | | Reactivity Profile | 3,3'-Dimethoxybenzidine dihydrochloride is an ether substituted acidic organic salt. Reacts weakly as a acid to neutralize bases. May react with strong oxidizing agents or strong reducing agents. | | Fire Hazard | Flash point data are not available for 3,3'-Dimethoxybenzidine dihydrochloride, but 3,3'-Dimethoxybenzidine dihydrochloride is probably combustible. | | Safety Profile | Confirmed carcinogen
with experimental carcinogenic and
tumorigenic data. Experimental
reproductive data. Mutation data reported.When heated to decomposition it emits very
toxic fumes of NO, and HCl. | | References | [1] MAMORU SUGIURA Kazuyuki H. A new colorimetric method for determination of serum glucose[J]. Clinica Chimica Acta, 1977, 75 3: Pages 387-391. DOI: 10.1016/0009-8981(77)90357-6
[2] M M MESULAM D L R. Sensitivity in horseradish peroxidase neurohistochemistry: a comparative and quantitative study of nine methods.[J]. Journal of Histochemistry & Cytochemistry, 1979, 27 3: 763-773. DOI: 10.1177/27.3.113450
[3] 3,3’-Dimethoxybenzidine and dyes metabolized to 3,3’-dimethoxybenzidine: 3,3’-dimethoxybenzidine.[J]. Report on carcinogens: carcinogen profiles, 2011, 12: 164-165.
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| | 3,3'-Dimethoxybenzidine dihydrochloride Preparation Products And Raw materials |
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