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| | L-2-Chlorophenylglycine Basic information |
| Product Name: | L-2-Chlorophenylglycine | | Synonyms: | (S)-AMINO-(2-CHLORO-PHENYL)-ACETIC ACID;(S)-(+)-ALPHA-AMINO-(2-CHLOROPHENYL)ACETIC ACID;(S)-(+)-A-AMINO-(2-CHLOROPHENYL)ACETIC ACID;(S)-(+)-2-CHLOROPHENYLGLYCINE;S-(+)-2-(2-CHLORO PHENYL)GLYCINE;L-(+)-2-CHLOROPHENYLGLYCINE;L-(2-CHLOROPHENYL)GLYCINE;(L)-(-)-ALPHA-AMINO-(2-CHLOROPHENYL)ACETIC ACID | | CAS: | 141315-50-6 | | MF: | C8H8ClNO2 | | MW: | 185.61 | | EINECS: | 604-231-3 | | Product Categories: | Amino ACIDS SERIES;pharmacetical;chiral | | Mol File: | 141315-50-6.mol |  |
| | L-2-Chlorophenylglycine Chemical Properties |
| Melting point | 182-187 °C(lit.) | | Boiling point | 318.8±32.0 °C(Predicted) | | density | 1.392±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | pka | 1.69±0.10(Predicted) | | form | Solid | | color | White to off-white | | Optical Rotation | [α]/D 79.0 to 90.0°, c =1 in methanol
[α]20/D +79°, c =1% in chloroform | | Major Application | peptide synthesis | | InChI | 1S/C8H8ClNO2/c9-6-4-2-1-3-5(6)7(10)8(11)12/h1-4,7H,10H2,(H,11,12)/t7-/m0/s1 | | InChIKey | LMIZLNPFTRQPSF-ZETCQYMHSA-N | | SMILES | N[C@H](C(O)=O)c1ccccc1Cl | | CAS DataBase Reference | 141315-50-6(CAS DataBase Reference) |
| WGK Germany | 3 | | HS Code | 2922498590 | | Storage Class | 13 - Non Combustible Solids | | Hazard Classifications | Aquatic Chronic 4 |
| | L-2-Chlorophenylglycine Usage And Synthesis |
| Chemical Properties | white to light yellow crystal powder | | Uses | L-2-Chlorophenylglycine | | Synthesis | The general procedure for the synthesis of (R)-2-amino-2-(2-chlorophenyl)acetic acid from sodium cyanide and o-chlorobenzaldehyde is as follows: 2-chlorophenylglycine was prepared according to the synthetic method described in Scheme 1. This was done as follows: 2-chlorobenzaldehyde, ammonium bicarbonate (NH4HCO3; 23.7 g) and sodium cyanide (NaCN; 14.7 g) were dissolved in a mixed solution of 500 ml of methanol and 500 ml of water, and the reaction was stirred for 5 hours at 65-70 °C. Upon completion of the reaction, the solution was concentrated and transferred to an autoclave, where 45% sodium hydroxide (NaOH) solution was added and refluxed at 120°C for 4 hours. After the reaction mixture was cooled, 2 g of activated carbon was added and stirred for 10 minutes for decolorization. The activated carbon was removed by filtration and the pH of the filtrate was adjusted to 7-8 with 50% sulfuric acid (H2SO4).Subsequently, the precipitate was collected by filtration and washed with distilled water to give a final product of 27 g (58% yield) of 2-chlorophenylglycine. The compound had a specific optical rotation of +0.16 (C=1, 1N HCl) and a melting point of 185.4-186.8 °C. | | References | [1] Patent: US2004/176637, 2004, A1. Location in patent: Page 3 |
| | L-2-Chlorophenylglycine Preparation Products And Raw materials |
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