| Company Name: |
Bide Pharmatech Ltd.
|
| Tel: |
400-400-164-7117 18317119277 |
| Email: |
product02@bidepharm.com |
| Products Intro: |
Product Name:Isopropyl (1-((5-chloro-8-hydroxyquinolin-7-yl)methyl)piperidin-4-yl)carbamate
CAS:1928763-08-9
Purity:98% Package:10mg;50mg;100mg;250mg Remarks:BD01171007
|
| Company Name: |
Shanghai YuanYe Biotechnology Co., Ltd.
|
| Tel: |
021-61312847; 18021002903 |
| Email: |
3008007409@qq.com |
| Products Intro: |
Product Name:ML418
CAS:1928763-08-9
Purity:98% Package:10mg;5mg;25mg;100mg
|
ML418 manufacturers
- ML418
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- $33.00 / 1mg
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2026-01-23
- CAS:1928763-08-9
- Min. Order:
- Purity: 99.30%
- Supply Ability: 10g
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| Product Name: | ML418 | | Synonyms: | ML418;Carbamic acid, N-[1-[(5-chloro-8-hydroxy-7-quinolinyl)methyl]-4-piperidinyl]-, 1-methylethyl ester;Isopropyl (1-((5-chloro-8-hydroxyquinolin-7-yl)methyl)piperidin-4-yl)carbamate;inhibit,ML-418,ML418,KcsA,ML 418,Inhibitor,Potassium Channel | | CAS: | 1928763-08-9 | | MF: | C19H24ClN3O3 | | MW: | 377.87 | | EINECS: | | | Product Categories: | | | Mol File: | 1928763-08-9.mol |  |
| | ML418 Chemical Properties |
| Boiling point | 545.5±50.0 °C(Predicted) | | density | 1.31±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | Soluble in DMSO | | form | Solid | | pka | 12.43±0.20(Predicted) | | color | White to off-white |
| | ML418 Usage And Synthesis |
| Uses | ML418 is a potent, selective and CNS penetrating Kir7.1 potassium channel blocker. ML418 inhibits Kir7.1 with an IC50 value of 0.31 μM. ML418 can be used for the research of neurological, cardiovascular, endocrine and muscle disorders. | | in vivo | ML418 (i.p.; 30 mg/kg) has good PK effect, excellent CNS penetration and favorable CNS distribution[1]. | Animal Model: | Rats and Mice[1] | | Dosage: | 30 mg/kg | | Administration: | Intraperitoneal | | Result: | Showed a suitable PK profile (Cmax = 0.20 μM and Tmax = 3 h), excellent CNS penetration with a mouse brain: Kp of 10.9, brain (323.9 ng/g): plasma (29.5 ng/mL). |
| | storage | Store at -20°C | | References | [1] ML418, et al. ML418: The First Selective, Sub-Micromolar Pore Blocker of Kir7.1 Potassium Channels. ACS Chem Neurosci. 2016 Jul 20;7(7):1013-23. DOI:10.1021/acschemneuro.6b00111 |
| | ML418 Preparation Products And Raw materials |
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