| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
- ML327
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- $42.00
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2026-07-27
- CAS:1883510-31-3
- Purity: 99.48%
- Supply Ability: 10g
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| Product Name: | ML-327 | | Synonyms: | ML-327;ML327;ML-327;ML 327;-327;3-Pyridinecarboxamide, 1,2-dihydro-2-oxo-N-[3-[[(5-phenyl-3-isoxazolyl)carbonyl]amino]propyl]-;N-(3-(2-Oxo-1,2-dihydropyridine-3-carboxamido)propyl)-5-phenylisoxazole-3-carboxamide;ML-327,Autophagy,Myc,Inhibitor,ML 327,ML327,inhibit,c-Myc;ML327, 10 mM in DMSO;Abmole M9309-2mg ML327 1883510-31-3 | | CAS: | 1883510-31-3 | | MF: | C19H18N4O4 | | MW: | 366.37 | | EINECS: | | | Product Categories: | | | Mol File: | 1883510-31-3.mol |  |
| | ML-327 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO : 32 mg/mL (87.34 mM) | | form | Solid | | color | White to off-white | | InChIKey | NNNDNXLMQAPQQQ-UHFFFAOYSA-N | | SMILES | [nH]1[c](c(ccc1)C(=O)NCCCNC(=O)c2n[o]c(c2)c3ccccc3)=O |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | ML-327 Usage And Synthesis |
| Uses | ML327 is a blocker of MYC which can also de-repress E-cadherin transcription and reverse Epithelial-to-Mesenchymal Transition (EMT). | | Biological Activity | ML327 is a regulator of E-cadherin transcription th at restores E-cadherin expression in cancer cell lines and partially reverses Epithelial-to-Mesenchymal Transition (EMT). It is a potent inducer of mesenchymal-to-epithelial transition (MET) in epithelial cancers. Apparently ML327 blocks MYC expression in neuroblastomas. It induces apoptosis in cancer cells and sensitizes Ewing sarcoma cells to TRAIL. | | in vivo | ML327 treatment significantly reduces tumor volume by three-fold over the two-week treatment period (p=0.02). Tumor explant weights are approximately three-fold smaller in the ML327-treated mice (p=0.01). Mice treated with ML327 lost 12% more body weight than vehicle treated mice. ML327 treatment results in a two-fold decrease in MYCN expression, confirming that ML327 inhibits xenograft MYCN expression (p=0.0035)[1]. |
| | ML-327 Preparation Products And Raw materials |
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