| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine manufacturers
- ML367
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- $40.00
-
2026-07-27
- CAS:381168-77-0
- Purity: 99.39%
- Supply Ability: 10g
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| | N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine Basic information |
| | N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO: ≥ 125 mg/mL (373.89 mM) | | form | Solid | | color | Light yellow to yellow |
| | N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine Usage And Synthesis |
| Uses | ML367 is a potent inhibitor of ATPase family AAA domain-containing protein 5 (ATAD5) stabilization, acts as a probe molecule that has low micromolar inhibitory activity. ML367 blocks DNA repair pathways, suppresses general DNA damage responses including RPA32-phosphorylation and CHK1-phosphorylation in response to UV irradiation[1]. | | Biological Activity | ML367 is a potent micromolar inhibitor of the ATPase family AAA domain-containing protein 5 (ATAD5). It blocks DNA repair pathways and general DNA damage responses, including UV-stimulated phosphorylation of RPA32 and phosphorylation of CHK1. | | in vitro | ML367 (0-40 μM, 16 hours) inhibits FLAG-ATAD5 stabilization in HEK293T cells in the presence or absence of 20 μM 5-FUrd. Western Blot Analysis < table class="zh_use_1"> | Cell Line: | HEK293T cells | | Concentration: | 0-40 μM in the presence or absence of 20 μM 5-Furd | | Incubation Time: | 16 hours | | Result: | Inhibited the increased ATAD5 protein levels induced by 5-Furd. | |
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