t-butyoxycarboxy-PEG4-phosphonic acid ethyl ester

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t-butyoxycarboxy-PEG4-phosphonic acid ethyl ester Basic information
Product Name:t-butyoxycarboxy-PEG4-phosphonic acid ethyl ester
Synonyms:t-butyoxycarboxy-PEG4-phosphonic acid ethyl ester;Boc-PEG4-phosphonic acid ethyl ester;NUN 91774;4,7,10,13,17-Pentaoxa-16-phosphanonadecanoic acid, 16-ethoxy-, 1,1-dimethylethyl ester, 16-oxide
CAS:1623791-77-4
MF:C19H39O9P
MW:442.48
EINECS:
Product Categories:
Mol File:1623791-77-4.mol
t-butyoxycarboxy-PEG4-phosphonic acid ethyl ester Structure
t-butyoxycarboxy-PEG4-phosphonic acid ethyl ester Chemical Properties
Boiling point 501.6±45.0 °C(Predicted)
density 1.084±0.06 g/cm3(Predicted)
Safety Information
MSDS Information
t-butyoxycarboxy-PEG4-phosphonic acid ethyl ester Usage And Synthesis
Descriptiont-butyoxycarboxy-PEG4-phosphonic acid ethyl ester contains a t-Boc protecting group and a phosphonic acid ethyl ester moiety. The t-butyl group is removed under acidic conditions. The hydrophilic PEG spacer increases solubility in aqueous media.
UsesBoc-PEG4-phosphonic acid ethyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50PEGs
References[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
t-butyoxycarboxy-PEG4-phosphonic acid ethyl ester Preparation Products And Raw materials
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