Carboxy-PEG4-phosphonic acid ethyl ester

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Carboxy-PEG4-phosphonic acid ethyl ester Basic information
Product Name:Carboxy-PEG4-phosphonic acid ethyl ester
Synonyms:Carboxy-PEG4-phosphonic acid ethyl ester;3-[2-[2-[2-(2-diethoxyphosphorylethoxy)ethoxy]ethoxy]ethoxy]propanoic acid;4,7,10,13,17-Pentaoxa-16-phosphanonadecanoic acid, 16-ethoxy-, 16-oxide
CAS:1964503-39-6
MF:C15H31O9P
MW:386.38
EINECS:
Product Categories:
Mol File:1964503-39-6.mol
Carboxy-PEG4-phosphonic acid ethyl ester Structure
Carboxy-PEG4-phosphonic acid ethyl ester Chemical Properties
Boiling point 508.0±50.0 °C(Predicted)
density 1.160±0.06 g/cm3(Predicted)
pka4.28±0.10(Predicted)
Safety Information
MSDS Information
Carboxy-PEG4-phosphonic acid ethyl ester Usage And Synthesis
DescriptionCarboxy-PEG4-phosphonic acid ethyl ester contains a carboxylic acid end group and a phosphonic acid ethyl ester moiety. The carboxylic acid can react with primary amines in the presence of activators such as EDC and HATU to form a stable amide bond. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media.
UsesCarboxy-PEG4-phosphonic acid ethyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50PEGs
References[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Carboxy-PEG4-phosphonic acid ethyl ester Preparation Products And Raw materials
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(2-{2-[2-(Diethoxy-phosphoryl)-ethoxy]-ethoxy}-ethyl)-phosphonic acid Diethyl ester Propargyl-PEG3-phosphonic acid ethyl ester t-butyoxycarboxy-PEG4-phosphonic acid ethyl ester Diethoxy-phosphorylethyl-PEG5-ethylphosphonic acid PEG3-bis-(ethyl phosphonate) PEG5-bis-(ethyl phosphonate)