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| | Propargyl-PEG3-phosphonic acid ethyl ester Basic information |
| Product Name: | Propargyl-PEG3-phosphonic acid ethyl ester | | Synonyms: | Propargyl-PEG3-phosphonic acid ethyl ester;Propargyl-PEG3-phosphonic acid diethyl ester;Phosphonic acid, P-[2-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]ethyl]-, diethyl ester;Propargyl-PEG3-Phosphonic Ester;Diethyl [2-[2-[2-(Prop-2-yn-1-yloxy)ethoxy]ethoxy]ethyl]phosphonate | | CAS: | 1052678-30-4 | | MF: | C13H25O6P | | MW: | 308.31 | | EINECS: | | | Product Categories: | | | Mol File: | 1052678-30-4.mol |  |
| | Propargyl-PEG3-phosphonic acid ethyl ester Chemical Properties |
| | Propargyl-PEG3-phosphonic acid ethyl ester Usage And Synthesis |
| Description | Propargyl-PEG3-phosphonic acid ethyl ester is a crosslinker containing a propargyl group and a phosphonic acid ethyl ester. The propargyl group can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. The hydrophilic PEG spacer increases solubility in aqueous media. | | Uses | Propargyl-PEG3-phosphonic acid diethyl ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Propargyl-PEG3-phosphonic acid diethyl ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | | IC 50 | PEGs | | References | [1] Thorsten Heidelberg, et al. Oligo-ethylene glycol based phosphonate surface modification reagents and use thereof. WO2015065168A1 |
| | Propargyl-PEG3-phosphonic acid ethyl ester Preparation Products And Raw materials |
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