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| | 2-AMINO-5-METHOXYPYRIMIDINE Basic information |
| | 2-AMINO-5-METHOXYPYRIMIDINE Chemical Properties |
| Melting point | 86-88°C | | Boiling point | 313℃ | | density | 1.224 | | Fp | 143℃ | | storage temp. | Keep in dark place,Inert atmosphere,2-8°C | | solubility | Chloroform, Methanol | | pka | 3.62±0.10(Predicted) | | form | Powder | | color | Off-white | | Sensitive | Air Sensitive | | CAS DataBase Reference | 13418-77-4 |
| | 2-AMINO-5-METHOXYPYRIMIDINE Usage And Synthesis |
| Chemical Properties | Yellow to Tan Solid | | Synthesis | General procedure for the synthesis of 2-amino-5-methoxypyrimidine using 2-chloro-5-methoxypyrimidine as starting material: 2-chloro-5-methoxypyrimidine (0.817 g, 5.65 mmol) and 25% aqueous ammonia solution were added to a microwave reaction vessel. The reaction vessel was sealed and the reaction was heated at 150 °C for 3 hours. After completion of the reaction, the mixture was evaporated to dryness. The resulting crude product was dissolved in dichloromethane/methanol (1:1, v/v) solvent mixture and loaded on silica gel. Purification by fast column chromatography (eluent: 50-100% ethyl acetate in heptane solution with gradient elution) afforded 2-amino-5-methoxypyrimidine as colorless crystals (386 mg, 55% yield).1H NMR (400 MHz, DMSO-d6) δ 8.02 (s, 1H), 6.06 (br s, 1H), 3.71 (s, 3H). | | References | [1] Patent: WO2008/141239, 2008, A1. Location in patent: Page/Page column 54
[2] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 5, p. 1261 - 1266 |
| | 2-AMINO-5-METHOXYPYRIMIDINE Preparation Products And Raw materials |
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