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16,16-DIMETHYL PROSTAGLANDIN E1

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16,16-DIMETHYL PROSTAGLANDIN E1 Basic information
Product Name:16,16-DIMETHYL PROSTAGLANDIN E1
Synonyms:9-OXO-11ALPHA,15R-DIHYDROXY-16,16-DIMETHYL-PROST-13E-EN-1-OIC ACID;16,16-dimethylprostaglandin E;Prost-13-en-1-oic acid, 11,15-dihydroxy-16,16-dimethyl-9-oxo-, (11alpha,13E,15R)-;RQOFITYRYPQNLL-ZWSAOQBFSA-N;16,16-dimethyl PGE1;9-oxo-11α,15R-dihydroxy-16,16-dimethyl-prost-13E-en-1-oic acid;16,16-DIMETHYL PROSTAGLANDIN E1;Prost-13-en-1-oic acid, 11,15-dihydroxy-16,16-dimethyl-9-oxo-, (11α,13E,15R)-
CAS:41692-15-3
MF:C22H38O5
MW:382.53
EINECS:
Product Categories:
Mol File:41692-15-3.mol
16,16-DIMETHYL PROSTAGLANDIN E1 Structure
16,16-DIMETHYL PROSTAGLANDIN E1 Chemical Properties
storage temp. Store at -20°C
solubility DMF: >100 mg/ml; DMSO: >50 mg/ml; Ethanol: >50 mg/ml; PBS pH 7.2: >1.6 mg/ml
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MSDS Information
16,16-DIMETHYL PROSTAGLANDIN E1 Usage And Synthesis
Description16,16-dimethyl PGE1 is a metabolically stable synthetic analog of PGE1. It induces human vascular smooth muscle contractions in vitro. It is 2, 3, and 6 times more potent than PGF2α in contracting tracheal, bronchial, and bronchiolar smooth muscle, respectively.1
Uses16,16-Dimethylprostaglandin E1 (16,16-dimethyl-PGE1) is a PGE1 (HY-B0131) analog, induces bronchoconstrict and vascular smooth muscle contractions and suppresses the indomethacin induced cellular elongation[1][2][3].
DefinitionChEBI: 16,16-dimethyl-PGE1 is a prostanoid.
in vivo

16,16-Dimethylprostaglandin E1 (1 μg/kgmin for 30 min) accelerates blood pressure and heart rate recovery rate, increases catecholamine turnover, enhances levels of epinephrine and norepinephrine in plasma following acute hemorrhage in Sprague Dawley rats[1].

Animal Model:Sprague-Dawley rats[1]
Dosage:1 μg/kgmin
Administration:0-30 min
Result:Improved blood pressure and heart rate, improved levels of epinephrine and norepinephrine im plasma.
References1. Karim, S.M.M., Adaikan, P.G., and Kottegoda, S.R. Prostaglandins and human respiratory tract smooth muscle: Structure activity relationship Adv. Prostaglandin Thromboxane Res. 7,969-980(1980).
16,16-DIMETHYL PROSTAGLANDIN E1 Preparation Products And Raw materials
Tag:16,16-DIMETHYL PROSTAGLANDIN E1(41692-15-3) Related Product Information
16,16-DIMETHYL-6-KETO PROSTAGLANDIN E1 16,16-DIMETHYL PROSTAGLANDIN E1 11-DEOXY PROSTAGLANDIN E1 1,11ALPHA,15S-TRIHYDROXY-PROST-13E-EN-9-ONE Prostaglandin E1 9-DEOXY-9-METHYLENE-16,16-DIMETHYL PROSTAGLANDIN E2