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| | E3 ligase Ligand-Linker Conjugates 34 Basic information |
| Product Name: | E3 ligase Ligand-Linker Conjugates 34 | | Synonyms: | cIAP1 Ligand-Linker Conjugates 15;E3 ligase Ligand-Linker Conjugates 34;2-[2-(2-aminoethoxy)ethoxy]ethyl (2S)-2-[[(2S,3R)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-2-hydroxy-4-phenyl-butanoyl]amino]-4-methyl-pentanoate;L-Leucine, N-[(2S,3R)-3-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-2-hydroxy-1-oxo-4-phenylbutyl]-, 2-[2-(2-aminoethoxy)ethoxy]ethyl ester | | CAS: | 1225433-96-4 | | MF: | C37H47N3O8 | | MW: | 661.78 | | EINECS: | | | Product Categories: | | | Mol File: | 1225433-96-4.mol |  |
| | E3 ligase Ligand-Linker Conjugates 34 Chemical Properties |
| Boiling point | 861.4±65.0 °C(Predicted) | | density | 1+-.0.06 g/cm3(Predicted) | | pka | 11.15±0.46(Predicted) |
| | E3 ligase Ligand-Linker Conjugates 34 Usage And Synthesis |
| Uses | cIAP1 Ligand-Linker Conjugates 15 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 15 can be used to design SNIPERs[1]. | | IC 50 | cIAP1 | | References | [1] Itoh Y, et al. Protein knockdown using methyl bestatin-ligand hybrid molecules: design and synthesis of inducers of ubiquitination-mediated degradation of cellular retinoic acid-binding proteins. J Am Chem Soc. 2010 Apr 28;132(16):5820-6. DOI:10.1021/ja100691p |
| | E3 ligase Ligand-Linker Conjugates 34 Preparation Products And Raw materials |
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