|
|
| | E3 ligase Ligand 11 Basic information |
| Product Name: | E3 ligase Ligand 11 | | Synonyms: | cIAP1 ligand 2;E3 ligase Ligand 11;Benzyl ((S)-1-(((S)-1-Cyclohexyl-2-((S)-2-(4-(3-hydroxybenzoyl)thiazol-2-yl)pyrrolidin-1-yl)-2-oxoethyl)amino)-1-oxopropan-2-yl)(methyl)carbamate;benzyl N-[(1S)-1-{[(1S)-1-cyclohexyl-2-[(2S)-2-[4-(3-hydroxybenzoyl)-1,3-thiazol-2-yl]pyrrolidin-1-yl]-2-oxoethyl]carbamoyl}ethyl]-N-methylcarbamate;Carbamic acid, N-[(1S)-2-[[(1S)-1-cyclohexyl-2-[(2S)-2-[4-(3-hydroxybenzoyl)-2-thiazolyl]-1-pyrrolidinyl]-2-oxoethyl]amino]-1-methyl-2-oxoethyl]-N-methyl-, phenylmethyl ester | | CAS: | 2357114-70-4 | | MF: | C34H40N4O6S | | MW: | 632.77 | | EINECS: | | | Product Categories: | | | Mol File: | 2357114-70-4.mol |  |
| | E3 ligase Ligand 11 Chemical Properties |
| Boiling point | 863.5±65.0 °C(Predicted) | | density | 1.286±0.06 g/cm3(Predicted) | | pka | 8.78±0.10(Predicted) |
| | E3 ligase Ligand 11 Usage And Synthesis |
| Uses | cIAP1 ligand 2 is the LCL161 derivative based IAP ligand. cIAP1 ligand 2 can be connected to the ABL ligand for protein by a linker to form SNIPER. | | IC 50 | cIAP1 | | References | [1] Shibata N, et al. Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands. J Med Chem. 2018 Jan 25;61(2):543-575. DOI:10.1021/acs.jmedchem.7b00168 |
| | E3 ligase Ligand 11 Preparation Products And Raw materials |
|