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| | E3 ligase Ligand-Linker Conjugates 38 Basic information |
| Product Name: | E3 ligase Ligand-Linker Conjugates 38 | | Synonyms: | cIAP1 Ligand-Linker Conjugates 12;E3 ligase Ligand-Linker Conjugates 38;Benzenesulfonic acid, 4-methyl-, 2-[2-[2-[2-[3-[[2-[(2S)-1-[(2S)-2-cyclohexyl-2-[[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]methylamino]-1-oxopropyl]amino]acetyl]-2-pyrrolidinyl]-4-thiazolyl]carbonyl]phenoxy]ethoxy]ethoxy]ethoxy]ethyl ester;tert-butyl N-[(1S)-1-{[(1S)-1-cyclohexyl-2-[(2S)-2-[4-(3-{2-[2-(2-{2-[(4-methylbenzenesulfonyl)oxy]ethoxy}ethoxy)ethoxy]ethoxy}benzoyl)-1,3-thiazol-2-yl]pyrrolidin-1-yl]-2-oxoethyl]carbamoyl}ethyl]-N-methylcarbamate | | CAS: | 2095244-52-1 | | MF: | C46H64N4O12S2 | | MW: | 929.15 | | EINECS: | | | Product Categories: | | | Mol File: | 2095244-52-1.mol |  |
| | E3 ligase Ligand-Linker Conjugates 38 Chemical Properties |
| Boiling point | 999.9±65.0 °C(Predicted) | | density | 1.239±0.06 g/cm3(Predicted) | | pka | 14.02±0.46(Predicted) |
| | E3 ligase Ligand-Linker Conjugates 38 Usage And Synthesis |
| Uses | cIAP1 Ligand-Linker Conjugates 12 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 12 can be used to design SNIPERs[1]. | | IC 50 | cIAP1 | | References | [1] Ohoka N, et al. In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs). J Biol Chem. 2017 Mar 17;292(11):4556-4570. DOI:10.1074/jbc.M116.768853 |
| | E3 ligase Ligand-Linker Conjugates 38 Preparation Products And Raw materials |
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