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| | E3 ligase Ligand-Linker Conjugates 37 Basic information |
| Product Name: | E3 ligase Ligand-Linker Conjugates 37 | | Synonyms: | cIAP1 Ligand-Linker Conjugates 2;E3 ligase Ligand-Linker Conjugates 37;12,15-Dioxa-2,6,9-triazaheptadecanoic acid, 17-amino-4-hydroxy-7-(2-methylpropyl)-5,8-dioxo-3-(phenylmethyl)-, 9H-fluoren-9-ylmethyl ester, (3R,4S,7S)- | | CAS: | 1312302-14-9 | | MF: | C37H48N4O7 | | MW: | 660.8 | | EINECS: | | | Product Categories: | | | Mol File: | 1312302-14-9.mol |  |
| | E3 ligase Ligand-Linker Conjugates 37 Chemical Properties |
| Boiling point | 921.3±65.0 °C(Predicted) | | density | 1.200±0.06 g/cm3(Predicted) | | pka | 11.15±0.46(Predicted) |
| | E3 ligase Ligand-Linker Conjugates 37 Usage And Synthesis |
| Uses | cIAP1 Ligand-Linker Conjugates 2 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 2 can be used to design SNIPERs[1]. | | IC 50 | cIAP1 | | References | [1] Itoh Y, et al. Design, synthesis and biological evaluation of nuclear receptor-degradation inducers. Bioorg Med Chem. 2011 Nov 15;19(22):6768-78. DOI:10.1016/j.bmc.2011.09.041 |
| | E3 ligase Ligand-Linker Conjugates 37 Preparation Products And Raw materials |
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