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| | 5,7-Dimethoxy-indan-1-one Basic information | | Uses |
| Product Name: | 5,7-Dimethoxy-indan-1-one | | Synonyms: | 5,7-Dimethoxy-1-indanone;5,7-diMethoxy-2,3-dihydro-1H-inden-1-one;5,7-dimethoxy-2,3-dihydroinden-1-one;2,3-Dihydro-5,7-dimethoxy-1H-inden-1-one;1H-Inden-1-one, 2,3-dihydro-5,7-dimethoxy-;5,7-Dimethoxy-indan-1-one | | CAS: | 880-87-5 | | MF: | C11H12O3 | | MW: | 192.21 | | EINECS: | | | Product Categories: | | | Mol File: | 880-87-5.mol |  |
| | 5,7-Dimethoxy-indan-1-one Chemical Properties |
| Melting point | 99-100 °C | | Boiling point | 352.6±42.0 °C(Predicted) | | density | 1.34 g/cm3 | | storage temp. | Sealed in dry,Room Temperature | | Appearance | Off-white to light yellow Solid |
| | 5,7-Dimethoxy-indan-1-one Usage And Synthesis |
| Uses | 5,7-Dimethoxyindan-1-one acts as a reagent for the preparation and antitumor activities of phenyl- and benzothiazolylisoquinolinedienes. | | Uses | 5,7-Dimethoxyindan-1-one acts as a reagent for the preparation and antitumor activities of phenyl- and benzothiazolylisoquinolinedienes. | | Synthesis | The general procedure for the synthesis of 5,7-dimethoxyindanone from 3,5-dimethoxyphenylpropionic acid was as follows: 3-(3,5-dimethoxyphenyl)propionic acid (2 g x 5) was dissolved in methanesulfonic acid (10 ml x 5) in a microwave treated vial (20 ml x 5). The reaction mixture was heated at 90°C for 10 min under microwave radiation. After completion of the reaction, the mixture was slowly poured into ice (250 g) and neutralized to pH 8-9 with 2 M NaOH solution, followed by extraction with EtOAc. The organic layers were combined and the target product 5,7-dimethoxyindanone (8.8 g, 96.2% yield) was obtained after concentration. The product was analyzed by LC-MS and showed m/e 193 (MH+). | | References | [1] Chemistry - An Asian Journal, 2015, vol. 10, # 4, p. 1050 - 1064
[2] Tetrahedron, 2007, vol. 63, # 2, p. 389 - 395
[3] Patent: WO2007/71348, 2007, A1. Location in patent: Page/Page column 87
[4] ChemMedChem, 2018, vol. 13, # 18, p. 1949 - 1956
[5] Tetrahedron Letters, 1980, vol. 21, # 37, p. 3603 - 3606 |
| | 5,7-Dimethoxy-indan-1-one Preparation Products And Raw materials |
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