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- Treosulfan
-
- $33.00
-
2026-07-20
- CAS:299-75-2
- Purity: 99.83%
- Supply Ability: 10g
- Treosulfan
-
- $46.00
-
2024-01-08
- CAS:299-75-2
- Min. Order: 1kg
- Purity: 99.50%
- Supply Ability: 20tons
- treosulfan
-
- $1.00
-
2020-01-15
- CAS:299-75-2
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1kg ,5kg, 50kg
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| | treosulfan Basic information |
| Product Name: | treosulfan | | Synonyms: | TREOSULPHAN;1,2,3,4-butanetetrol 1,4-dimethanesulfonate;(2S,3S)-1-O,4-O-Di(methylsulfonyl)-L-threitol;CB-2562;L-Dihydroxy-Busulfan;Leo 40067;NSC 39069;THREOSULFAN | | CAS: | 299-75-2 | | MF: | C6H14O8S2 | | MW: | 278.3 | | EINECS: | 206-081-0 | | Product Categories: | API | | Mol File: | 299-75-2.mol |  |
| | treosulfan Chemical Properties |
| Melting point | 76-78 °C | | Boiling point | 359.3°C (rough estimate) | | density | 1.305 (estimate) | | refractive index | 1.5630 (estimate) | | storage temp. | Store at -20°C | | solubility | Acetone (Slightly), DMSO (Slightly), Methanol (Slightly), Water (Slightly) | | pka | 12.36±0.20(Predicted) | | form | Solid | | color | Off-White to Pale Beige | | Optical Rotation | [α]/D -4.9 to -5.9°, c =1 in acetone | | Water Solubility | H2O: 5mg/mL, clear | | InChI | InChI=1S/C6H14O8S2/c1-15(9,10)13-3-5(7)6(8)4-14-16(2,11)12/h5-8H,3-4H2,1-2H3/t5-,6-/m0/s1 | | InChIKey | YCPOZVAOBBQLRI-WDSKDSINSA-N | | SMILES | C(OS(C)(=O)=O)[C@H](O)[C@@H](O)COS(C)(=O)=O | | CAS DataBase Reference | 299-75-2 | | IARC | 1 (Vol. 26, Sup 7, 100A) 2012 | | EPA Substance Registry System | Treosulfan (299-75-2) |
| RIDADR | 2811 | | WGK Germany | WGK 3 | | HazardClass | 6.1(b) | | PackingGroup | III | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Carc. 1A
Muta. 1B
Repr. 2 | | Hazardous Substances Data | 299-75-2(Hazardous Substances Data) | | Toxicity | LDLo intravenous in dog: 222mg/kg |
| | treosulfan Usage And Synthesis |
| Uses | Treosulfan is used as myeloablative agent in conditioning regimen prior to allogeneic hematopoietic stem cell transplantation (HSCT). It can also be an effective agent for conditioning children with inborn errors of immunity (IEI). | | Definition | ChEBI: Treosulfan is a methanesulfonate ester. | | General Description | Odorless white crystalline powder. | | Air & Water Reactions | Water soluble. Slowly hydrolyzes: decomposes within 3 hours at pH 7.5 and 77°F. . | | Fire Hazard | Flash point data for treosulfan are not available; however, treosulfan is probably combustible. | | Biological Activity | Treosulfan is a biofunctional alkylating agent.', 'Treosulfan is bifunctional alkylating agent.', 'Treosulfan/l-threitol-1,4-bis-methanesulfonate; dihydroxybusulfan; NSC 39069. It is a prodrug of a bifunctional alkylating cytotoxic agent. Treosulfan can be activated non-enzymatically to two active epoxides. It is used to tre at ovarian cancer. | | Clinical Use | Alkylating agent for ovarian cancer | | Safety Profile | Confirmed carcinogen.
Poison by intravenous route. Human
mutation data reported. When heated to
decomposition it emits toxic fumes of SOx. | | Metabolism | Treosulfan is a prodrug of a bifunctional alkylating agent, converted in vivo to epoxide compounds. Approximately 30
% of the substance is excreted unchanged in the urine within 24 hours, nearly 90
% of which is within the first 6 hours after administration. |
| | treosulfan Preparation Products And Raw materials |
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