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(R)-(+)-trans-4-(1-Aminoethyl)-N-(4-pyridyl)cyclohexanecarboxamide Dihydrochloride Monohydrate

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(R)-(+)-trans-4-(1-Aminoethyl)-N-(4-pyridyl)cyclohexanecarboxamide Dihydrochloride Monohydrate Basic information
Product Name:(R)-(+)-trans-4-(1-Aminoethyl)-N-(4-pyridyl)cyclohexanecarboxamide Dihydrochloride Monohydrate
Synonyms:(R)-(+)-trans-4-(1-Aminoethyl)-N-(4-pyridyl)cyclohexanecarboxamide Dihydrochloride Monohydrate;trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinyl-cyclohexanecarboxamide Dihydrochloride Monohydrate;Cyclohexanecarboxamide, 4-[(1R)-1-aminoethyl]-N-4-pyridinyl-, dihydrochloride, monohydrate, trans- (9CI);(R)-(+)-trans-4-(1-Aminoethyl)-N-(4-Pyridyl)cyclohexanecarboxamide monohydrate dihydrochloride;Y-27632 monohydrate dihydrochloride;Y-27632 Dihydrochloride Hydrate;Y-27632 dihydrochloride monohydrate;Y-27632 2HCl Monohydrate
CAS:331752-47-7
MF:C14H25Cl2N3O2
MW:0
EINECS:
Product Categories:Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Protein Kinase Inhibitors and Activators;All Inhibitors;Pfizer Compounds
Mol File:331752-47-7.mol
(R)-(+)-trans-4-(1-Aminoethyl)-N-(4-pyridyl)cyclohexanecarboxamide Dihydrochloride Monohydrate Structure
(R)-(+)-trans-4-(1-Aminoethyl)-N-(4-pyridyl)cyclohexanecarboxamide Dihydrochloride Monohydrate Chemical Properties
Melting point 180-230°C
Boiling point approximate 85℃
alpha +2~+10°(D/20℃)(c=0.5,CH3OH)
storage temp. 2-8°C
solubility Acetonitrile (Very Slightly), DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form Solid
color White to Off-White
Water Solubility water: 100mg/mL
Stability:Hygroscopic; Light Sensitive;
InChI1S/C14H21N3O/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13/h6-12H,2-5,15H2,1H3,(H,16,17,18)/t10-,11,12/m1/s1
InChIKeyIYOZTVGMEWJPKR-VOMCLLRMSA-N
SMILESN[C@@H](C1CCC(CC1)C(=O)Nc2ccncc2)C
CAS DataBase Reference331752-47-7
Safety Information
Hazard Codes Xn
Risk Statements 20/21/22
Safety Statements 36
WGK Germany WGK 3
Storage Class11 - Combustible Solids
MSDS Information
(R)-(+)-trans-4-(1-Aminoethyl)-N-(4-pyridyl)cyclohexanecarboxamide Dihydrochloride Monohydrate Usage And Synthesis
Chemical PropertiesWhite Solid
UsesA Rho kinase inhibitor (ROCK) for the treatment of ischemia-reperfusion disorders. Potent ROCK inhibitor
Biological ActivityCell permeable: yes', 'Primary Target
p160 Rho-associated protein kinases (ROCK)', 'Product competes with ATP.', 'Reversible: yes', 'Target Ki: 140 nM for p160 Rho-associated protein kinases (ROCK)
(R)-(+)-trans-4-(1-Aminoethyl)-N-(4-pyridyl)cyclohexanecarboxamide Dihydrochloride Monohydrate Preparation Products And Raw materials
Tag:(R)-(+)-trans-4-(1-Aminoethyl)-N-(4-pyridyl)cyclohexanecarboxamide Dihydrochloride Monohydrate(331752-47-7) Related Product Information
N-pyridin-4-ylpiperidine-4-carboxamide dihydrochloride 4-Amino-N-(pyridin-4-yl)butanamide dihydrochloride 2,2-Dimethyl-N-pyridin-4-yl-propionamide Y-27632 Cyclohexanecarboxamide, 4-[(1R)-1-aminoethyl]-N-4-pyridinyl-, hydrochloride (1:1), trans- 4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylcyclohexanecarboxamide