- Gracillin
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- $44.00
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2026-07-15
- CAS:19083-00-2
- Purity: 99.86%
- Supply Ability: 10g
- Gracillin
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2024-04-12
- CAS:19083-00-2
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 2000ton
- Gracillin
-
-
2023-02-24
- CAS:19083-00-2
- Min. Order: 5mg
- Purity: ≥98%(HPLC)
- Supply Ability: 10 g
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| | gracillin Basic information |
| | gracillin Chemical Properties |
| Melting point | 290-293℃ (DEC.) | | density | 1.42 | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | solubility | Soluble in DMSO, methanol and pyridine | | form | powder | | pka | 12.78±0.70(Predicted) | | color | White | | Major Application | food and beverages | | InChI | InChI=1S/C15H20O3/c1-8-4-5-11(16)15(3)7-6-10-9(2)14(17)18-13(10)12(8)15/h9-10,13H,4-7H2,1-3H3 | | InChIKey | RSDQBPGKMDFRHH-UHFFFAOYSA-N | | SMILES | C12=C(C)CCC(=O)C1(C)CCC1C(C(=O)OC21)C |
| WGK Germany | WGK 3 | | HS Code | 29329990 | | Storage Class | 11 - Combustible Solids |
| | gracillin Usage And Synthesis |
| Description | Gracillin is a steroidal saponin that has been found in C. speciosus and has diverse biological activities. It reduces cell growth in a panel of 58 leukemia, non-small cell lung, colon, CNS, prostate, melanoma, ovarian, renal, and breast cancer cell lines (GI50s = 0.58-2.44 μM). Gracillin reduces growth of fish Ich parasite (I. multifiliis) theronts (EC50 = 0.53 mg/L) and induces 100 and 92.5% mortality of I. multifiliis protomonts and encysted tomonts, respectively, when used at a concentration of 0.8 mg/L. It decreases the number of I. multifiliis-infected goldfish by approximately 75% when used at a concentration of 1 mg/L in tank water. Gracillin (100 mg/kg) reduces ear edema induced by arachidonic acid in mice. | | Chemical Properties | White powder, soluble in organic solvents such as methanol, ethanol, DMSO, etc., derived from the rhizomes of Dioscorea zingiberensis and Dioscorea parviflora. | | Uses | Gracillin is a steroidal glycoside from the rhizomes of the family Dioscoreaceae with potential anti-proliferative effects. | | Definition | ChEBI: Gracillin is a triterpenoid. | | in vivo | Gracillin (oral gavage, 10mg/kg for xenografts and 20mg/kg for PDX) inhibits tumor growth of xenograft tumors inoculating lung (H1299), prostate (DU145), and colorectum (HCT116) cancer cells, as well as patient-derived xenograft colon and lung tumors[1].
| | References | [1] KE HU Xinsheng Y. The cytotoxicity of methyl protoneogracillin (NSC-698793) and gracillin (NSC-698787), two steroidal saponins from the rhizomes of Dioscorea collettii var. hypoglauca, against human cancer cells in vitro.[J]. Phytotherapy Research, 2003, 17 6: 620-626. DOI: 10.1002/ptr.1211
[2] WEI ZHENG. Antiparasitic efficacy of Gracillin and Zingibernsis newsaponin from Costus speciosus (Koen ex. Retz) Sm. against Ichthyophthirius multifiliis.[J]. Parasitology, 2015, 142 3: 473-479. DOI: 10.1017/s0031182014001358
[3] SUNG YONG KIM. Inhibition of mouse ear edema by steroidal and triterpenoid saponins[J]. Archives of Pharmacal Research, 1999, 22 3: 313-316. DOI: 10.1007/bf02976370 |
| | gracillin Preparation Products And Raw materials |
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