Ogremorphin manufacturers
- Ogremorphin
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- $399.00
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2026-05-18
- CAS:352563-21-4
- Purity: 99.65%
- Supply Ability: 10g
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| | Ogremorphin Basic information |
| Product Name: | Ogremorphin | | Synonyms: | Ogremorphin;GPR68-IN-1|||OGM;Spiro[3H-indole-3,2′(3′H)-[1,3,4]thiadiazol]-2(1H)-one, 5-ethyl-5′-(1-naphthalenyl)-;5-Ethyl-5'-(naphthalen-1-yl)-3'H-spiro[indoline-3,2'-[1,3,4]thiadiazol]-2-one | | CAS: | 352563-21-4 | | MF: | C21H17N3OS | | MW: | 359.45 | | EINECS: | | | Product Categories: | | | Mol File: | 352563-21-4.mol |  |
| | Ogremorphin Chemical Properties |
| density | 1.391±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | form | Solid | | pka | 7.282±0.40(predicted) | | color | Yellow to orange |
| | Ogremorphin Usage And Synthesis |
| Uses | Ogremorphin (OGM) is a G protein coupled sensor GPR68 inhibitor with anti-inflammatory and anti-tumor activities. Ogremorphin can inhibit the migration of human melanoma cells and induce ferroptosis in glioblastoma cells[1][2][3]. | | in vivo | Ogremorphin can alleviate vascular leakage, pulmonary inflammation, and pulmonary endothelial dysfunction caused by intratracheal injection of LPS or acidosis in mice[1].
Ogremorphin (10 μM) can cause abnormal melanocyte pigmentation and developmental disorders in zebrafish embryos[3]. | Animal Model: | Zebrafish[3]. | | Dosage: | 10 μM | | Administration: | Added to a 96 well microtiter plate (5 embryos/well) arranged with zebrafish fertilized eggs | | Result: | Induced phenotypes encompassing a wavy notochord, abnormal pigmentation, craniofacial defects, ventral curvature, and a shortened body axis. |
| | References | [1] Karki P, et al. A Novel Group of Ogremorphin Inhibitors Targeting G Protein-coupled Sensor GPR68 Rescue Lipopolysaccharide or Acidosis-induced Lung Endothelial Dysfunction[M]//C108. MECHANISMS OF LUNG INFLAMMATION AND INFECTION. American Thoracic Society, 2024: A6846-A6846.
[2] Williams C H, et al. Coupling Metastasis to pH-Sensing GPR68 Using a Novel Small Molecule Inhibitor[J]. BioRxiv, 2019: 612549.
[3] Williams C H, et al. GPR68-ATF4 signaling is a novel prosurvival pathway in glioblastoma activated by acidic extracellular microenvironment. Exp Hematol Oncol. 2024 Jan 31;13(1):13. DOI:10.1186/s40164-023-00468-1 |
| | Ogremorphin Preparation Products And Raw materials |
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