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| | Diethyl 2-Ethyl-2-methylmalonate Basic information |
| Product Name: | Diethyl 2-Ethyl-2-methylmalonate | | Synonyms: | ethyl-methyl-malonicaciddiethylester;2-Ethyl-2-methylmalonic Acid Diethyl Ester;Diethyl 2-Ethyl-2-methylmalonate;2-Ethyl-2-methylpropanedioic acid diethyl ester;2-Methyl-2-ethylmalonic acid diethyl ester;Butane-2,2-dicarboxylic acid diethyl ester;Methylethylmalonic acid diethyl ester;diethyl 2-ethyl-2-methylpropanedioate | | CAS: | 2049-70-9 | | MF: | C10H18O4 | | MW: | 202.25 | | EINECS: | 218-070-8 | | Product Categories: | | | Mol File: | 2049-70-9.mol |  |
| | Diethyl 2-Ethyl-2-methylmalonate Chemical Properties |
| Boiling point | 62 °C0.35 mm Hg(lit.) | | density | 0.981 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.42(lit.) | | Fp | 198 °F | | form | clear liquid | | color | Colorless to Almost colorless | | CAS DataBase Reference | 2049-70-9(CAS DataBase Reference) |
| WGK Germany | 1 | | HS Code | 2917198090 |
| | Diethyl 2-Ethyl-2-methylmalonate Usage And Synthesis |
| Uses |
Diethyl 2-Ethyl-2-methylmalonate is a crucial compound that could be used as a pharmaceutical intermediate in pharmaceutical synthesis and scientific research.
| | Synthesis | To a stirred solution of 40.0 grams (0.23 mole) of diethyl 2-methylmalonate and 50.2 grams (0.46 mole) of bromoethane in 200 ml of dry dimethylformamide was added 79.5 grams (0.58 mole) of potassium carbonate. The resulting mixture was stirred at ambient temperature for 16 hours. A sample of the reaction mixture was subjected to analysis by vapor phase chromatography (VPC), which indicated the reaction had not gone to completion. An additional 50.2 grams of bromoethane was added and the reaction mixture stirred at ambient temperature for three days. VPC analysis indicated the reaction to be 80.9% complete. The reaction mixture was heated to 50° C. where it was stirred for one day. VPC analysis at this time indicated the reaction to be 88.8% complete. The reaction mixture was filtered and the filter cake washed with 200 ml of methylene chloride. The filtrate was diluted with 500 ml of methylene chloride and the combination washed with three portions of 500 ml each of water. The organic layer was dried with magnesium sulfate and filtered. The filtrate was concentrated under reduced pressure to a residual oil. The oil was distilled under reduced pressure to give 40.9 grams of diethyl 2-ethyl-2-methylmalonate; bp 109°-112° C./25 mm. |
| | Diethyl 2-Ethyl-2-methylmalonate Preparation Products And Raw materials |
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