- 4-Chloropyrazole
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- $10.70
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2026-05-28
- CAS:15878-00-9
- Min. Order: 10kg
- Purity: 99%
- Supply Ability: 10000kg
- 4-Chloropyrazole
-
-
2025-06-27
- CAS:15878-00-9
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 500000kg
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| | 4-Chloropyrazole Basic information |
| Product Name: | 4-Chloropyrazole | | Synonyms: | VITAS-BB TBB000653;AKOS B001464;4-CHLOROPYRAZOLE;4-chloro-1h-pyrazol;ART-CHEM-BB B001464;4-chloro-pyrazol;1H-Pyrazole, 4-chloro-;4-chloro-1H-pyrazole(SALTDATA: FREE) | | CAS: | 15878-00-9 | | MF: | C3H3ClN2 | | MW: | 102.52 | | EINECS: | | | Product Categories: | john's | | Mol File: | 15878-00-9.mol |  |
| | 4-Chloropyrazole Chemical Properties |
| Melting point | 75-76 ºC | | Boiling point | 220 ºC | | density | 1.405 | | Fp | 99 ºC | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | form | powder to crystal | | pka | 12.71±0.50(Predicted) | | color | White to Almost white | | λmax | 224nm(lit.) | | InChI | InChI=1S/C3H3ClN2/c4-3-1-5-6-2-3/h1-2H,(H,5,6) | | InChIKey | BADSZRMNXWLUKO-UHFFFAOYSA-N | | SMILES | N1C=C(Cl)C=N1 | | CAS DataBase Reference | 15878-00-9(CAS DataBase Reference) |
| Hazard Codes | Xi,Xn | | Risk Statements | 36/37/38-22 | | Safety Statements | 26-36/37/39 | | WGK Germany | WGK 3 | | RTECS | UQ6445000 | | HazardClass | IRRITANT | | HS Code | 2933199090 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Irrit. 2
Skin Sens. 1 |
| | 4-Chloropyrazole Usage And Synthesis |
| Chemical Properties | White to light yellow crystalline powder | | Synthesis | General method: synthesis of 1-benzyl-4-chloro-3,5-dimethyl-1H-pyrazole. To a 16 mL reaction vial containing 1-benzyl-3,5-dimethyl-1H-pyrazole (196 mg, 1.05 mmol) and a magnetic stirrer, 0.7 mL of water and 0.3 mL of ethyl acetate were added sequentially. Subsequently, sodium chloride (123 mg, 2 mmol) was added and the reaction flask was placed in a room temperature water bath to control the exothermic nature of the reaction. Next, Oxone (322 mg, 0.52 mmol KHSO5) was added and the reaction vial was sealed. The reaction was carried out under continuous vigorous stirring until thin layer chromatography (TLC) analysis (1 h) showed complete consumption of the feedstock. The remaining oxidant was reduced by addition of solid sodium bisulfite until starch iodide paper tested negative. The reaction mixture was diluted with water (5 mL) and extracted with a 1:1 hexane/ether solvent mixture (3 x 5 mL). The organic phases were combined, dried with anhydrous magnesium sulfate and concentrated under reduced pressure to give the crude product. The crude product was purified by fast column chromatography (14×1 cm, eluent 9:1 hexane/ethyl acetate) to afford pure 1-benzyl-4-chloro-3,5-dimethyl-1H-pyrazole as a light yellow oil (215 mg, 93% yield). | | References | [1] Canadian Journal of Chemistry, 1991, vol. 69, # 3, p. 432 - 439
[2] Journal of Heterocyclic Chemistry, 2014, vol. 51, # 6, p. 1621 - 1627
[3] Tetrahedron Letters, 2017, vol. 58, # 43, p. 4111 - 4114
[4] Advanced Synthesis and Catalysis, 2013, vol. 355, # 2-3, p. 499 - 507
[5] Angewandte Chemie - International Edition, 2016, vol. 55, # 52, p. 16132 - 16135 |
| | 4-Chloropyrazole Preparation Products And Raw materials |
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